A neurobehavioral perspective on inhibitory control and depression in adolescent girls: The role of rumination

The goals of this project were to examine (a) the concurrent and prospective associations between inhibitory control (as defined by performance, as well as neural activation and functional connectivity [FC] during the socially aversive relative to control and socially appetitive relative to control conditions on a socioemotional Go/no-go task) and depressive symptoms in adolescent girls; and (b) the mediating role of rumination. Participants included 90 mid-adolescent girls (Mage = 16.31 years, SD = .84, age range = 14.9 – 17.7) who completed a diagnostic interview, questionnaires, and a modified socioemotional Go/no-go task during an fMRI scan session. Depressive symptoms were associated with (a) less amygdala-cerebellum anterior lobe FC, more amygdala-precuneus, -posterior cingulate, and -right dorsolateral prefrontal cortex (dlPFC) FC, as well as more right dlPFC-precuneus FC during the socially aversive relative to control condition; and (b) more amygdala-superior temporal gyrus, -cingulate gyrus, -postcentral gyrus, and -right dlPFC FC, as well as more right dlPFC-postcentral gyrus FC during the socially appetitive relative to control condition. Rumination was associated with more amygdala-precuneus FC during the socially aversive relative to control condition. Finally, rumination partially mediated the association between amygdala-precuneus FC and concurrent depressive symptoms. Together, these results suggest that heightened neural processing of socioemotional information may represent a marker for depressive symptoms, and more effort by regulatory regions may be required to maintain inhibitory performance in depressed adolescent girls.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Psychology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2023

Author dc:creator

• Modi, Haina

Contributors dc:contributor

• Rudolph, Karen D
• Heller, Wendy
• Pomerantz, Eva
• Telzer, Eva H
• Troop-Gordon, Wendy

• Adolescence
• Depression
• Inhibitory Control
• Functional Connectivity
• Rumination

Statement dc:rights

• Copyright 2023 Haina Modi

Language dc:language

en, eng

Handle dc:identifier

https://hdl.handle.net/2142/122026

OAI record oai:identifier

https://www.ideals.illinois.edu/oai-pmh?verb=GetRecord&metadataPrefix=etdms&identifier=oai%3Awww.ideals.illinois.edu%3A2142%2F122026