Functional particles for controlled release and cell surface engineering

Engineered polymer vesicles (polymersome) have emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large molecules of interest. With the capacity to engineer and compartmentalize the properties of these particles, they can be tailored with unique design specifics to meet different applications. In this regard, the overall goal of my thesis research is to construct a functional polymersome system by implementing stimuli-responsiveness and surface modification to overcome various biological challenges. Chapter 2 demonstrates a stimuli-responsive particle with an enhanced release profile as a new formulation pathway to assemble the hemostatic fibrin-based matrix. Chapter 3 presents a polymersome-based cell adherent nanostimulator for enhanced stem cell paracrine factor secretion. I further demonstrated applications of these particle platforms in the treatment of hindlimb ischemia associate with chronic kidney disease (Chapter 4) and the delivery of CD44-binding particles for enhanced retention in aged mice associated with Alzheimer’s disease (Chapter 5). Overall, these studies present a deeper understanding of how to incorporate engineering strategies to construct functional hemostatic gelators and nanostimulator to enhance the biological efficacy of molecular and cell therapies.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2021

Author dc:creator

• Hong, Yu-Tong

Contributors dc:contributor

• Kong, Hyunjoon
• Kraft, Mary L
• Rogers, Simon A
• Boppart, Marni

• Nanoparticle
• Stem Cell Engineering
• Controlled Release, Surface Modification
• Biological Gel

Statement dc:rights

• Permission not required

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/110815

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/110815