{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/110815"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/110815","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Functional particles for controlled release and cell surface engineering","abstract":"Engineered polymer vesicles (polymersome) have emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large molecules of interest. With the capacity to engineer and compartmentalize the properties of these particles, they can be tailored with unique design specifics to meet different applications. In this regard, the overall goal of my thesis research is to construct a functional polymersome system by implementing stimuli-responsiveness and surface modification to overcome various biological challenges. Chapter 2 demonstrates a stimuli-responsive particle with an enhanced release profile as a new formulation pathway to assemble the hemostatic fibrin-based matrix. Chapter 3 presents a polymersome-based cell adherent nanostimulator for enhanced stem cell paracrine factor secretion. I further demonstrated applications of these particle platforms in the treatment of hindlimb ischemia associate with chronic kidney disease (Chapter 4) and the delivery of CD44-binding particles for enhanced retention in aged mice associated with Alzheimer’s disease (Chapter 5). Overall, these studies present a deeper understanding of how to incorporate engineering strategies to construct functional hemostatic gelators and nanostimulator to enhance the biological efficacy of molecular and cell therapies.","abstract_html":"Engineered polymer vesicles (polymersome) have emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large molecules of interest. With the capacity to engineer and compartmentalize the properties of these particles, they can be tailored with unique design specifics to meet different applications. In this regard, the overall goal of my thesis research is to construct a functional polymersome system by implementing stimuli-responsiveness and surface modification to overcome various biological challenges. Chapter 2 demonstrates a stimuli-responsive particle with an enhanced release profile as a new formulation pathway to assemble the hemostatic fibrin-based matrix. Chapter 3 presents a polymersome-based cell adherent nanostimulator for enhanced stem cell paracrine factor secretion. I further demonstrated applications of these particle platforms in the treatment of hindlimb ischemia associate with chronic kidney disease (Chapter 4) and the delivery of CD44-binding particles for enhanced retention in aged mice associated with Alzheimer’s disease (Chapter 5). Overall, these studies present a deeper understanding of how to incorporate engineering strategies to construct functional hemostatic gelators and nanostimulator to enhance the biological efficacy of molecular and cell therapies.","abstract_has_math":false,"creators":["Hong, Yu-Tong"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Kong, Hyunjoon","Kraft, Mary L","Rogers, Simon A","Boppart, Marni"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2021,"date_issued":"2021-09-17T04:04:26Z","date_published":"2021-09-17T04:04:26Z","updated_at":"2026-07-22T22:24:52Z","subjects":["Nanoparticle","Stem Cell Engineering","Controlled Release, Surface Modification","Biological Gel"],"languages":["en"],"rights":["Permission not required"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/110815","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kong, Hyunjoon","Kraft, Mary L","Rogers, Simon A","Boppart, Marni"]},{"key":"dc:creator","label":"Author","values":["Hong, Yu-Tong"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2021-09-17T04:04:26Z","2023-09-17T04:07:01Z","2021-04-19","2021-05"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Nanoparticle","Stem Cell Engineering","Controlled Release, Surface Modification","Biological Gel"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Permission not required"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/110815"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Engineered polymer vesicles (polymersome) have emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large molecules of interest. With the capacity to engineer and compartmentalize the properties of these particles, they can be tailored with unique design specifics to meet different applications. In this regard, the overall goal of my thesis research is to construct a functional polymersome system by implementing stimuli-responsiveness and surface modification to overcome various biological challenges. Chapter 2 demonstrates a stimuli-responsive particle with an enhanced release profile as a new formulation pathway to assemble the hemostatic fibrin-based matrix. Chapter 3 presents a polymersome-based cell adherent nanostimulator for enhanced stem cell paracrine factor secretion. I further demonstrated applications of these particle platforms in the treatment of hindlimb ischemia associate with chronic kidney disease (Chapter 4) and the delivery of CD44-binding particles for enhanced retention in aged mice associated with Alzheimer’s disease (Chapter 5). Overall, these studies present a deeper understanding of how to incorporate engineering strategies to construct functional hemostatic gelators and nanostimulator to enhance the biological efficacy of molecular and cell therapies.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-05-01","The student, Yu-Tong Hong, accepted the attached license on 2021-04-15 at 13:03.","The student, Yu-Tong Hong, submitted this Dissertation for approval on 2021-04-15 at 13:14.","This Dissertation was approved for publication on 2021-04-19 at 09:21.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16349 on 2021-09-16 at 20:09:58","Made available in DSpace on 2021-09-17T04:04:26Z (GMT). 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These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large molecules of interest. With the capacity to engineer and compartmentalize the properties of these particles, they can be tailored with unique design specifics to meet different applications. In this regard, the overall goal of my thesis research is to construct a functional polymersome system by implementing stimuli-responsiveness and surface modification to overcome various biological challenges. Chapter 2 demonstrates a stimuli-responsive particle with an enhanced release profile as a new formulation pathway to assemble the hemostatic fibrin-based matrix. Chapter 3 presents a polymersome-based cell adherent nanostimulator for enhanced stem cell paracrine factor secretion. I further demonstrated applications of these particle platforms in the treatment of hindlimb ischemia associate with chronic kidney disease (Chapter 4) and the delivery of CD44-binding particles for enhanced retention in aged mice associated with Alzheimer’s disease (Chapter 5). Overall, these studies present a deeper understanding of how to incorporate engineering strategies to construct functional hemostatic gelators and nanostimulator to enhance the biological efficacy of molecular and cell therapies.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-05-01","The student, Yu-Tong Hong, accepted the attached license on 2021-04-15 at 13:03.","The student, Yu-Tong Hong, submitted this Dissertation for approval on 2021-04-15 at 13:14.","This Dissertation was approved for publication on 2021-04-19 at 09:21.","DSpace SAF Submission Ingestion Package generated from Vireo submission #16349 on 2021-09-16 at 20:09:58","Made available in DSpace on 2021-09-17T04:04:26Z (GMT). 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