Discrete frequency mid-infrared spectroscopic imaging using quantum cascade lasers

Infrared (IR) spectroscopic imaging is an analytical technique that directly images the spatial distribution of chemical components within a sample in the absence of external contrast agents. This is especially advantageous with biological samples where the mid to far-infrared wavelength range corresponds with the vibrational modes of functional groups in many organic molecules. In recent years, the technology enabling discrete frequency infrared (DFIR) spectroscopic microscopy has undergone many substantive changes due to rapid developments in quantum cascade lasers (QCL) in terms of their output power, beam stability, and wavelength tuning range. In this dissertation, we present the research and development of several state-of-the-art microscopy systems that have advanced what was previously possible with industry standard instruments. Through drastic improvements in imaging speed and resolution, as well as reductions in noise and aberrations, our systems serve as a flexible platform with capabilities that open new avenues for research and clinical interests.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Bioengineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2019

Author dc:creator

• Yeh, Kevin

Contributors dc:contributor

• Bhargava, Rohit
• Irudayaraj, Joseph Maria Kumar
• Pan, Dipanjan
• Kajdacsy-Balla, Andre

• Chemical imaging, infrared spectroscopy, quantum cascade laser

Statement dc:rights

• Copyright 2019 Kevin Yeh

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/105846

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/105846