{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/105846"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/105846","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Discrete frequency mid-infrared spectroscopic imaging using quantum cascade lasers","abstract":"Infrared (IR) spectroscopic imaging is an analytical technique that directly images the spatial distribution of chemical components within a sample in the absence of external contrast agents. This is especially advantageous with biological samples where the mid to far-infrared wavelength range corresponds with the vibrational modes of functional groups in many organic molecules. In recent years, the technology enabling discrete frequency infrared (DFIR) spectroscopic microscopy has undergone many substantive changes due to rapid developments in quantum cascade lasers (QCL) in terms of their output power, beam stability, and wavelength tuning range. In this dissertation, we present the research and development of several state-of-the-art microscopy systems that have advanced what was previously possible with industry standard instruments. Through drastic improvements in imaging speed and resolution, as well as reductions in noise and aberrations, our systems serve as a flexible platform with capabilities that open new avenues for research and clinical interests.","abstract_html":"Infrared (IR) spectroscopic imaging is an analytical technique that directly images the spatial distribution of chemical components within a sample in the absence of external contrast agents. This is especially advantageous with biological samples where the mid to far-infrared wavelength range corresponds with the vibrational modes of functional groups in many organic molecules. In recent years, the technology enabling discrete frequency infrared (DFIR) spectroscopic microscopy has undergone many substantive changes due to rapid developments in quantum cascade lasers (QCL) in terms of their output power, beam stability, and wavelength tuning range. In this dissertation, we present the research and development of several state-of-the-art microscopy systems that have advanced what was previously possible with industry standard instruments. Through drastic improvements in imaging speed and resolution, as well as reductions in noise and aberrations, our systems serve as a flexible platform with capabilities that open new avenues for research and clinical interests.","abstract_has_math":false,"creators":["Yeh, Kevin"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Bhargava, Rohit","Irudayaraj, Joseph Maria Kumar","Pan, Dipanjan","Kajdacsy-Balla, Andre"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-11-26T20:56:41Z","date_published":"2019-11-26T20:56:41Z","updated_at":"2026-07-22T22:24:45Z","subjects":["Chemical imaging, infrared spectroscopy, quantum cascade laser"],"languages":["en"],"rights":["Copyright 2019 Kevin Yeh"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/105846","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bhargava, Rohit","Irudayaraj, Joseph Maria Kumar","Pan, Dipanjan","Kajdacsy-Balla, Andre"]},{"key":"dc:creator","label":"Author","values":["Yeh, Kevin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-11-26T20:56:41Z","2021-11-27T10:15:34Z","2019-07-12","2019-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemical imaging, infrared spectroscopy, quantum cascade laser"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2019 Kevin Yeh"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/105846"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Infrared (IR) spectroscopic imaging is an analytical technique that directly images the spatial distribution of chemical components within a sample in the absence of external contrast agents. 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Through drastic improvements in imaging speed and resolution, as well as reductions in noise and aberrations, our systems serve as a flexible platform with capabilities that open new avenues for research and clinical interests.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-08-01","The student, Kevin Yeh, accepted the attached license on 2019-07-10 at 18:47.","The student, Kevin Yeh, submitted this Dissertation for approval on 2019-07-12 at 11:32.","This Dissertation was approved for publication on 2019-07-12 at 12:51.","DSpace SAF Submission Ingestion Package generated from Vireo submission #11988 on 2019-11-26 at 13:59:04","Made available in DSpace on 2019-11-26T20:56:41Z (GMT). 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