A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles

X-ray-activated photodynamic therapy (X-PDT) techniques have gained traction for its potential to impart therapeutic effects at greater depths than possible with traditional photodynamic therapy [1], [2]. Interestingly, the underlying X-PDT process could also generate X-ray fluorescence (XF) with metal-based nanoparticles (NPs) and X-ray luminescence (XL), which could be used to monitor the delivery of PDT agents and the subsequent therapeutic process. This allows the possibility of using X-ray fluorescence (XFCT) and X-ray luminescence computed tomography (XLCT) to monitor the therapeutic delivery during radiation therapy. X-ray Raleigh scattering (XRS) produced by the scattered monochromatic incident X-ray can also be correlated with the data from XFCT/XLCT while X-ray transmission CT (XT CT) could provide structural information. This work demonstrates a proof-of-concept of a XF-XL -XT CT imaging platform that allows for quantitative imaging of the X-ray PDT delivery process through complementary contrast mechanisms, and demonstrates this platform’s ability to image X-PDT nanophosphors, such as Y2O3:Eu3+. This work also attempts to address the limitations of the system—sensitivity, acquisition time, and dosage—by examining how incoming X-ray irradiation schemes affect the X-ray fluorescent and X-ray luminescent yields as well as overall X-ray fluorescent image quality. Results show that choosing an optimized incident X-ray spectrum can maximize fluorescent and luminescent yields as well as improve image quality. This in conjunction with improvements in geometric efficiency through a multi-slit ring of detectors has the potential to bring the multi-modality system into a preclinical setting.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nuclear, Plasma, Radiolgc Engr

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2018

Author dc:creator

• George, Jonathan

Contributors dc:contributor

• Meng, Ling-Jian
• Abbaszadeh, Shiva
• Smith, Andrew
• Stubbins, James F.

• X-ray
• Nanoparticle
• Fluorescence
• Luminescence
• Imaging

Statement dc:rights

• Copyright 2017 Jonathan George

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/101107

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/101107