{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/101107"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/101107","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"A tri-modality x-ray fluorescence, x-ray luminescence, x-ray transmission computed tomography imaging platform for monitoring and stimulating metal-containing nanoparticles","abstract":"X-ray-activated photodynamic therapy (X-PDT) techniques have gained traction for its potential to impart therapeutic effects at greater depths than possible with traditional photodynamic therapy [1], [2]. Interestingly, the underlying X-PDT process could also generate X-ray fluorescence (XF) with metal-based nanoparticles (NPs) and X-ray luminescence (XL), which could be used to monitor the delivery of PDT agents and the subsequent therapeutic process. This allows the possibility of using X-ray fluorescence (XFCT) and X-ray luminescence computed tomography (XLCT) to monitor the therapeutic delivery during radiation therapy. X-ray Raleigh scattering (XRS) produced by the scattered monochromatic incident X-ray can also be correlated with the data from XFCT/XLCT while X-ray transmission CT (XT CT) could provide structural information. This work demonstrates a proof-of-concept of a XF-XL -XT CT imaging platform that allows for quantitative imaging of the X-ray PDT delivery process through complementary contrast mechanisms, and demonstrates this platform’s ability to image X-PDT nanophosphors, such as Y2O3:Eu3+. This work also attempts to address the limitations of the system—sensitivity, acquisition time, and dosage—by examining how incoming X-ray irradiation schemes affect the X-ray fluorescent and X-ray luminescent yields as well as overall X-ray fluorescent image quality. Results show that choosing an optimized incident X-ray spectrum can maximize fluorescent and luminescent yields as well as improve image quality. This in conjunction with improvements in geometric efficiency through a multi-slit ring of detectors has the potential to bring the multi-modality system into a preclinical setting.","abstract_html":"X-ray-activated photodynamic therapy (X-PDT) techniques have gained traction for its potential to impart therapeutic effects at greater depths than possible with traditional photodynamic therapy [1], [2]. Interestingly, the underlying X-PDT process could also generate X-ray fluorescence (XF) with metal-based nanoparticles (NPs) and X-ray luminescence (XL), which could be used to monitor the delivery of PDT agents and the subsequent therapeutic process. This allows the possibility of using X-ray fluorescence (XFCT) and X-ray luminescence computed tomography (XLCT) to monitor the therapeutic delivery during radiation therapy. X-ray Raleigh scattering (XRS) produced by the scattered monochromatic incident X-ray can also be correlated with the data from XFCT/XLCT while X-ray transmission CT (XT CT) could provide structural information. This work demonstrates a proof-of-concept of a XF-XL -XT CT imaging platform that allows for quantitative imaging of the X-ray PDT delivery process through complementary contrast mechanisms, and demonstrates this platform’s ability to image X-PDT nanophosphors, such as Y2O3:Eu3+. This work also attempts to address the limitations of the system—sensitivity, acquisition time, and dosage—by examining how incoming X-ray irradiation schemes affect the X-ray fluorescent and X-ray luminescent yields as well as overall X-ray fluorescent image quality. Results show that choosing an optimized incident X-ray spectrum can maximize fluorescent and luminescent yields as well as improve image quality. This in conjunction with improvements in geometric efficiency through a multi-slit ring of detectors has the potential to bring the multi-modality system into a preclinical setting.","abstract_has_math":false,"creators":["George, Jonathan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nuclear, Plasma, Radiolgc Engr","degree_department":null,"school":null,"contributors":["Meng, Ling-Jian","Abbaszadeh, Shiva","Smith, Andrew","Stubbins, James F."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-09-04T20:33:44Z","date_published":"2018-09-04T20:33:44Z","updated_at":"2026-07-22T22:24:38Z","subjects":["X-ray","Nanoparticle","Fluorescence","Luminescence","Imaging"],"languages":["en"],"rights":["Copyright 2017 Jonathan George"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/101107","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Meng, Ling-Jian","Abbaszadeh, Shiva","Smith, Andrew","Stubbins, James F."]},{"key":"dc:creator","label":"Author","values":["George, Jonathan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-09-04T20:33:44Z","2020-09-05T09:15:26Z","2017-12-21","2018-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nuclear, Plasma, Radiolgc Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["X-ray","Nanoparticle","Fluorescence","Luminescence","Imaging"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2017 Jonathan George"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/101107"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["X-ray-activated photodynamic therapy (X-PDT) techniques have gained traction for its potential to impart therapeutic effects at greater depths than possible with traditional photodynamic therapy [1], [2]. Interestingly, the underlying X-PDT process could also generate X-ray fluorescence (XF) with metal-based nanoparticles (NPs) and X-ray luminescence (XL), which could be used to monitor the delivery of PDT agents and the subsequent therapeutic process. This allows the possibility of using X-ray fluorescence (XFCT) and X-ray luminescence computed tomography (XLCT) to monitor the therapeutic delivery during radiation therapy. X-ray Raleigh scattering (XRS) produced by the scattered monochromatic incident X-ray can also be correlated with the data from XFCT/XLCT while X-ray transmission CT (XT CT) could provide structural information. This work demonstrates a proof-of-concept of a XF-XL -XT CT imaging platform that allows for quantitative imaging of the X-ray PDT delivery process through complementary contrast mechanisms, and demonstrates this platform’s ability to image X-PDT nanophosphors, such as Y2O3:Eu3+. This work also attempts to address the limitations of the system—sensitivity, acquisition time, and dosage—by examining how incoming X-ray irradiation schemes affect the X-ray fluorescent and X-ray luminescent yields as well as overall X-ray fluorescent image quality. Results show that choosing an optimized incident X-ray spectrum can maximize fluorescent and luminescent yields as well as improve image quality. 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Interestingly, the underlying X-PDT process could also generate X-ray fluorescence (XF) with metal-based nanoparticles (NPs) and X-ray luminescence (XL), which could be used to monitor the delivery of PDT agents and the subsequent therapeutic process. This allows the possibility of using X-ray fluorescence (XFCT) and X-ray luminescence computed tomography (XLCT) to monitor the therapeutic delivery during radiation therapy. X-ray Raleigh scattering (XRS) produced by the scattered monochromatic incident X-ray can also be correlated with the data from XFCT/XLCT while X-ray transmission CT (XT CT) could provide structural information. This work demonstrates a proof-of-concept of a XF-XL -XT CT imaging platform that allows for quantitative imaging of the X-ray PDT delivery process through complementary contrast mechanisms, and demonstrates this platform’s ability to image X-PDT nanophosphors, such as Y2O3:Eu3+. 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