Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis

Disruption of fluid homeostasis results in tissue edema, a hallmark of clinical conditions such as lymphedema. Despite significant advances in lymphatic biology, lymphedema remains a chronic and incurable disorder, largely due to an incomplete understanding of the mechanisms that regulate edema fluid clearance. In this study, we established a novel zebrafish model of edema. We utilized its optical transparency and intravital imaging capabilities to characterize the dynamic lymphatic responses during edema formation and resolution. Using this platform, we identified key structural and molecular changes that accompany compensatory lymphangiogenesis. Additionally, we investigated the role of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in mediating lymphatic vessel function and promoting edema resolution. Together, our findings elucidate the cellular and molecular mechanisms that govern lymphatic remodeling and fluid clearance, providing new insights into the fundamental processes that maintain tissue fluid balance.

Author dc:creator

• Olamide Olayinka (23291617)

• Health Sciences
• Pharmacology

Statement dc:rights

• In Copyright

DOI dc:identifier

https://doi.org/10.25417/uic.31451368.v1

OAI identifier oai:identifier

oai:figshare.com:article/31451368