{"id":{"repo_id":"uic","oai_identifier":"oai:figshare.com:article/31451368"},"canonical_url":"https://search.dev.ndltd.org/etd/uic/oai:figshare.com:article/31451368","repository":{"repo_id":"uic","name":"University of Illinois - Chicago","base_url":"https://api.figshare.com/v2/oai"},"display":{"title":"Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis","abstract":"Disruption of fluid homeostasis results in tissue edema, a hallmark of clinical conditions such as lymphedema. Despite significant advances in lymphatic biology, lymphedema remains a chronic and incurable disorder, largely due to an incomplete understanding of the mechanisms that regulate edema fluid clearance. In this study, we established a novel zebrafish model of edema. We utilized its optical transparency and intravital imaging capabilities to characterize the dynamic lymphatic responses during edema formation and resolution. Using this platform, we identified key structural and molecular changes that accompany compensatory lymphangiogenesis. Additionally, we investigated the role of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in mediating lymphatic vessel function and promoting edema resolution. Together, our findings elucidate the cellular and molecular mechanisms that govern lymphatic remodeling and fluid clearance, providing new insights into the fundamental processes that maintain tissue fluid balance.","abstract_html":"Disruption of fluid homeostasis results in tissue edema, a hallmark of clinical conditions such as lymphedema. Despite significant advances in lymphatic biology, lymphedema remains a chronic and incurable disorder, largely due to an incomplete understanding of the mechanisms that regulate edema fluid clearance. In this study, we established a novel zebrafish model of edema. We utilized its optical transparency and intravital imaging capabilities to characterize the dynamic lymphatic responses during edema formation and resolution. Using this platform, we identified key structural and molecular changes that accompany compensatory lymphangiogenesis. Additionally, we investigated the role of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in mediating lymphatic vessel function and promoting edema resolution. Together, our findings elucidate the cellular and molecular mechanisms that govern lymphatic remodeling and fluid clearance, providing new insights into the fundamental processes that maintain tissue fluid balance.","abstract_has_math":false,"creators":["Olamide Olayinka (23291617)"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-12-01T00:00:00Z","date_published":"2025-12-01T00:00:00Z","updated_at":"2026-07-27T21:34:25Z","subjects":["Health Sciences","Pharmacology"],"languages":[],"rights":["In Copyright"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://doi.org/10.25417/uic.31451368.v1","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Olamide Olayinka (23291617)"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-12-01T00:00:00Z"]},{"key":"dc:relation","label":"Dc Relation","values":["https://figshare.com/articles/thesis/Mechanisms_of_Edema_Clearance_The_Central_Role_of_Lymphatic_Vessels_and_LYVE1_in_Fluid_Homeostasis/31451368"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences","Pharmacology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.25417/uic.31451368.v1"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Disruption of fluid homeostasis results in tissue edema, a hallmark of clinical conditions such as lymphedema. Despite significant advances in lymphatic biology, lymphedema remains a chronic and incurable disorder, largely due to an incomplete understanding of the mechanisms that regulate edema fluid clearance. In this study, we established a novel zebrafish model of edema. We utilized its optical transparency and intravital imaging capabilities to characterize the dynamic lymphatic responses during edema formation and resolution. Using this platform, we identified key structural and molecular changes that accompany compensatory lymphangiogenesis. Additionally, we investigated the role of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in mediating lymphatic vessel function and promoting edema resolution. Together, our findings elucidate the cellular and molecular mechanisms that govern lymphatic remodeling and fluid clearance, providing new insights into the fundamental processes that maintain tissue fluid balance."]},{"key":"dc:title","label":"Title","values":["Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis"]}]}],"canonical_facts":{"dc:creator":["Olamide Olayinka (23291617)"],"dc:date":["2025-12-01T00:00:00Z"],"dc:description":["Disruption of fluid homeostasis results in tissue edema, a hallmark of clinical conditions such as lymphedema. Despite significant advances in lymphatic biology, lymphedema remains a chronic and incurable disorder, largely due to an incomplete understanding of the mechanisms that regulate edema fluid clearance. In this study, we established a novel zebrafish model of edema. We utilized its optical transparency and intravital imaging capabilities to characterize the dynamic lymphatic responses during edema formation and resolution. Using this platform, we identified key structural and molecular changes that accompany compensatory lymphangiogenesis. Additionally, we investigated the role of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in mediating lymphatic vessel function and promoting edema resolution. Together, our findings elucidate the cellular and molecular mechanisms that govern lymphatic remodeling and fluid clearance, providing new insights into the fundamental processes that maintain tissue fluid balance."],"dc:identifier":["10.25417/uic.31451368.v1"],"dc:relation":["https://figshare.com/articles/thesis/Mechanisms_of_Edema_Clearance_The_Central_Role_of_Lymphatic_Vessels_and_LYVE1_in_Fluid_Homeostasis/31451368"],"dc:rights":["In Copyright"],"dc:subject":["Health Sciences","Pharmacology"],"dc:title":["Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T21:34:25Z"}