Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1160 for “"Pharmacology"”.
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Paediatric Dexmedetomidine Pharmacology
Dexmedetomidine is a highly selective alpha-2 adrenoceptor agonist. Use is increasing in the paediatric setting, but without the concomitant understanding of the pharmacokinetics and pharmacodynamics to ensure safe and effective dosing. In this thesis the pharmacokinetics and pharmacodynamics of …
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Pharmacology of gastric cancer chemotherapy
Thesis is about pathology, etiology, pharmacotherapies and other therapies of gastric cancer
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Differential pharmacology of amphetamine enantiomers
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Physiology and pharmacology of flatworm muscle
<p>Pharmacological characterization of voltage-operated Ca2+ channels (VOCCs), in both free-living and parasitic flatworms, has been difficult since the currents carried by these channels are small in amplitude and run down quickly. While the presence of VOCCs in the parasite Schistosoma mansoni …
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Function and pharmacology of TRPM3 ion channel
For many ion channels there are few, if any, pharmacological agents, and even fewer showing specificity. In this study, a set of pharmacological tools were developed to investigate TRPM3, a widely expressed transient receptor potential (TRP) channel for which no functional role has yet been …
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Synthesis and Molecular Pharmacology of the Diazonamides
Diazonamide A is structurally novel, marine-derived natural product potently capable of inhibiting the growth of the cultured human cancer cell lines in vitro. Following the eassignment of diazonamide structure in 2001, we began a program to understand the compound's cellular mode of action. I …
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Rapid analysis of pharmacology for infectious diseases.
<p>Infectious diseases represent a multitude of threats to populations in both the developed and developing world, from the emergence of drug resistant bacteria and new pathogens to the ancient killers of the neglected topical diseases. Yet a common problem unites all infectious diseases, that is …
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Molecular pharmacology of an insect GABA receptor
Cys-loop receptors are ligand-gated ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila melanogaster and is a major target site for …
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Silibinin pharmacology and opportunities for therapy in horses
Milk thistle extracts have been used as a 'liver tonic' for centuries. In recent years, silibinin, the active ingredient in milk thistle extracts, has been studied both in vitro and in vivo to evaluate the beneficial effects in hepatic disease. It is evident from this research that silibinin …
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
… the current research, we conducted preclinical pharmacology studies of nutlin-3a to evaluate the synergistic effect of the nutlin-3a and topotecan combination on neuroblastoma cell growth, to assess the effect of nutlin-3a on breast cancer resistance protein (BCRP), and to characterize the …
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Single-Molecule Studies of CFTR Gating and Pharmacology
<p>The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel expressed in the apical membrane of epithelial tissues. Alterations in CFTR that disrupt activity cause cystic fibrosis, a fatal disease which is characterized by systemic salt and fluid dysregulation. By …
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Biochemical pharmacology of nucleotide metabolism in rat hepatoma
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The physiology and pharmacology of some cellulose derivatives
Increasing knowledge in physics and chemistry has stimulated research on high polymers, or to use another term, on macromolecules and on their applications in various fields. The definition of macromolecules given in 1922 by Staudinger and Fritschi states that a macromolecule is a compound with …
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The Clinical Pharmacology of Acetaminophen in Adult Horses
Non-steroidal anti-inflammatory drugs (NSAIDs) are a mainstay of the management of pain and inflammation associated with musculoskeletal disorders and systemic inflammation in horses. The most utilized NSAIDs in equine practice are non-selective cyclooxygenase (COX) inhibitors, such as flunixin …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
The goal of this escalating single-dose phase I research study was to determine the safety, tolerability, pharmacokinetics, pharmacodynamics as well as in vitro metabolism and plasma protein binding of MS-275, a novel histone deacetylase inhibitor, in patients with solid tumors and lymphomas. A …
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Toxicology and pharmacology of N¹-acetylspermidine and N⁸-acetylspermidine
<p>The polyamines are a group of natural compounds which have been found in almost all living tissues. N<sup>1</sup>- and N<sup>8</sup>- acetylspermidine have been known for a considerable time as normal constituents in human urine, but their physiological role is unknown. Recent studies have …
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An Investigation into the pharmacology of the ghrelin receptor
… of ghrelin. This study sought to investigate the pharmacology of the GRLN-R through the Gai/o pathway. [35S]GTPyS binding assays were used to measure activation of the Gai/o pathway, demonstrating that GHRP-6, L-692,585 (a commercially available analogue of L-692,429) and a third growth hormone …
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Pharmacology of novel approaches designed to target picornaviral infections
Many Picornaviridae family members infect humans. Enterovirus (EV), the largest genus, causes diseases ranging from the common cold to fatal heart disease and paralysis. Human parechoviruses (HPeV) are at least as prevalent as EVs. Currently, no antipicornavirus drugs are used clinically and the …
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