The Interaction of a Mutant Gene, Paddlefoot (Pf), and a Teratogen, 6-Azauridine, on Limb Development in Two Inbred Strains of Mice.

It is well known that mutant genes and environmental agents acting alone will induce developmental malformations. Within the past twenty-five years, more attention has been given to the interaction of the whole genome and specific mutant genes with either chemical or physical teratogens. Results of such studies have been reported in chickens, Drosophila and mammals (Landauer, '48, '60, '65; Goldschmidt and Piternick, '57; Barber, '59; Beck, '63, '64; Dagg, '66, '67, '72; Forsthoefel, '72, '75; Johnson, '70; Hamburgh et al., '70; Winfield and Bennett, '71; Musgrove, '73). Based on these investigations, several generalizations have been made concerning gene-teratogen interactions: (1) The frequency of a particular malformation, induced by a gene or teratogen alone, varies between different strains of the same species (Landauer, 1960). These differences are attributable to the action of many genes operating together rather than to the action of a single gene. (2) Teratogens, which induce phenotypic effects similar to mutant genes, may interact with these mutant genes to generate an enhanced effect on the embryo. (3) Modifying genes which affect the expression of a mutant gene may similarly affect teratogens which induce homologous defects.

Level thesis:degree_level

Thesis

Year

1976

Author dc:creator

• Coggin, Cherry Celeste

• Mammals
• Drosophila
• Gene-teratogen interactions
• Physical teratogens
• Genome

Repository record dc:identifier

https://digitalcommons.library.uab.edu/etd-collection/7143

OAI identifier oai:identifier

oai:digitalcommons.library.uab.edu:etd-collection-8135