Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 5045 for “"Genome"”.
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Genome
Collection of poetry.
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Tiger: tiled iterative genome assembler and approximate multi-genome aligner
… on sequence assembly qualities, especially for genomes having high repetitions. As more affordable raw data and assembled genomes are accessible to the community, there is an emerging demand for genome searches among the big amount of divergent genomes in gene banks. The genomes can be in the …
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Genome complexity reduction for genome-wide single nucleotide polymorphism analysis
… (SNPs) have been identified in the human genome, and more are cataloged every day. The challenge now is to use these SNPs to discover the genetic risk factors underlying common and complex diseases. Efficient, large-scale genotyping methods are one necessary component of this endeavor. …
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Exact genome alignment
… data due to the decrease in the cost of whole genome sequencing techniques has opened up new avenues of research in the field of Bioinformatics, like comparative genomics and evolutionary dynamics. The fundamental task in these studies is to align the genome sequences accurately. Sequence …
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Vibrionaceae genome dynamics
… of publicly available *Vibrionaceae* such as genome GC%, genome length, codon bias, plasmids, virulence and AMR genes are identified across the family in this research. From this a subset of genomes focused around *V. cholerae*, *V. vulnificus* and *V. parahaemolyticus* were selected for more …
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The complete plastid genome sequence of Passiflora cincinnata: genome rearrangements, massive plastid gene losses and implications to genome-plastome incompatibility
The plastid genome (plastome) organization, gene content and order is well conserved in most angiosperms, but there are some exceptions. The Passiflora genus is one of those exceptions, because there are evidences of some unusual plastid gene losses to species of this genus. However, none plastome …
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Regulatory of genome maintenance
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Dynamics of Genome Organization
… the dynamics underlying the organization of the genome are much less known. In this thesis I present my contributions to our understanding of these dynamics, working towards a full four-dimensional characterization of genome organization. First, by pulling on a genomic locus in live cells, we …
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Security of our Personal Genome
Our personal genome, which is the map of our DNA, is our ultimate source of identity, which should be given our highest concern for security. The primary approach used for securing any highly sensitive health care data such as our genome would be to guard against any personal identity information …
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Computational methods for genome screening
… encode. The development of new technologies for genome sequencing in the last years, opened new fundamental problems since huge amounts of biological data still deserve an interpretation. Indeed, the sequencing is only the first step of the genome annotation process that consists in the …
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Genome engineering in saccharomyces cerevisiae
… mutations globally and iteratively in a genome. In the rest of this dissertation, I sought to develop a new method, RNA-interference assisted genome evolution (RAGE), to apply directed evolution strategy in genome scale engineering of S. cerevisiae. A functional RNA interference (RNAi) …
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Genome organization in transcriptional regulation
… of cell identity, development, and disease. Genome organization contributes to transcriptional regulation in multiple ways. At a fundamental level, the genome is organized into distinct active and repressive chromatin states that facilitate transcriptional regulation. These chromatin states …
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Genome organization by loop extrusion
All livings cells propagate in the same way - they duplicate their chromosomes and divide into two daughter cells, each containing one copy of each chromosome. Because of the extreme length of chromosomes, their two copies have be compacted in order to be successfully segregated from each other. …
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Unfolding genome organization in interphase
Genomic contact frequency maps obtained from high throughput chromosome conformation capture technologies have revealed several organizing patterns of mammalian interphase chromosomes, including self-interacting topologically associating domains (TADs) which are believed to function as coherent …
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Transcriptional regulation and genome structure
… of the gene. Thus the structuring of the genome into DNA loops is important in the control of gene expression. This thesis will focus on the role of genome structure in transcriptional regulation. Two key questions in this area that I have attempted to address during my PhD are "how are …
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Towards a Genome Reverse Compiler
The Genome Reverse Compiler (GRC) is an annotation tool for prokaryotic genomes. Its name and philosophy are based on analogy with a high-level programming language compiler. In this analogy, the genome is a program in a certain low-level language that humans cannot understand. Given the sequence …
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Ancestral Genome Reconstruction in Bacteria
The rapid accumulation of numerous sequenced genomes has provided a golden opportunity for ancestral state reconstruction studies, especially in the whole genome reconstruction area. However, most ancestral genome reconstruction methods developed so far only focus on gene or replicon sequences …
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Decoding DNA: scalable genome annotation software, generative AI, and application to the cactus pear genome
The annotation of protein-coding genes from a raw genome assembly involves identifying the sequence regions that are transcribed into mRNA transcripts, spliced, and ultimately translated into protein. Thus, genome annotation is a fundamental task that critically supports systems level biological …
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