{"id":{"repo_id":"uab","oai_identifier":"oai:digitalcommons.library.uab.edu:etd-collection-8135"},"canonical_url":"https://search.dev.ndltd.org/etd/uab/oai:digitalcommons.library.uab.edu:etd-collection-8135","repository":{"repo_id":"uab","name":"University of Alabama Birmingham","base_url":"https://digitalcommons.library.uab.edu/do/oai/"},"display":{"title":"The Interaction of a Mutant Gene, Paddlefoot (Pf), and a Teratogen, 6-Azauridine, on Limb Development in Two Inbred Strains of Mice.","abstract":"It is well known that mutant genes and environmental agents acting alone will induce developmental malformations. Within the past twenty-five years, more attention has been given to the interaction of the whole genome and specific mutant genes with either chemical or physical teratogens. Results of such studies have been reported in chickens, Drosophila and mammals (Landauer, '48, '60, '65; Goldschmidt and Piternick, '57; Barber, '59; Beck, '63, '64; Dagg, '66, '67, '72; Forsthoefel, '72, '75; Johnson, '70; Hamburgh et al., '70; Winfield and Bennett, '71; Musgrove, '73). Based on these investigations, several generalizations have been made concerning gene-teratogen interactions: (1) The frequency of a particular malformation, induced by a gene or teratogen alone, varies between different strains of the same species (Landauer, 1960). These differences are attributable to the action of many genes operating together rather than to the action of a single gene. (2) Teratogens, which induce phenotypic effects similar to mutant genes, may interact with these mutant genes to generate an enhanced effect on the embryo. (3) Modifying genes which affect the expression of a mutant gene may similarly affect teratogens which induce homologous defects.","abstract_html":"It is well known that mutant genes and environmental agents acting alone will induce developmental malformations. Within the past twenty-five years, more attention has been given to the interaction of the whole genome and specific mutant genes with either chemical or physical teratogens. Results of such studies have been reported in chickens, Drosophila and mammals (Landauer, '48, '60, '65; Goldschmidt and Piternick, '57; Barber, '59; Beck, '63, '64; Dagg, '66, '67, '72; Forsthoefel, '72, '75; Johnson, '70; Hamburgh et al., '70; Winfield and Bennett, '71; Musgrove, '73). Based on these investigations, several generalizations have been made concerning gene-teratogen interactions: (1) The frequency of a particular malformation, induced by a gene or teratogen alone, varies between different strains of the same species (Landauer, 1960). These differences are attributable to the action of many genes operating together rather than to the action of a single gene. (2) Teratogens, which induce phenotypic effects similar to mutant genes, may interact with these mutant genes to generate an enhanced effect on the embryo. (3) Modifying genes which affect the expression of a mutant gene may similarly affect teratogens which induce homologous defects.","abstract_has_math":false,"creators":["Coggin, Cherry Celeste"],"institution":null,"degree_name":null,"degree_level":"Thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1976,"date_issued":"1976-01-01T08:00:00Z","date_published":"1976-01-01T08:00:00Z","updated_at":"2026-07-24T05:05:46Z","subjects":["Mammals","Drosophila","Gene-teratogen interactions","Physical teratogens","Genome"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.library.uab.edu/etd-collection/7143","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Coggin, Cherry Celeste"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mammals","Drosophila","Gene-teratogen interactions","Physical teratogens","Genome"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.library.uab.edu/etd-collection/7143"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["It is well known that mutant genes and environmental agents acting alone will induce developmental malformations. Within the past twenty-five years, more attention has been given to the interaction of the whole genome and specific mutant genes with either chemical or physical teratogens. Results of such studies have been reported in chickens, Drosophila and mammals (Landauer, '48, '60, '65; Goldschmidt and Piternick, '57; Barber, '59; Beck, '63, '64; Dagg, '66, '67, '72; Forsthoefel, '72, '75; Johnson, '70; Hamburgh et al., '70; Winfield and Bennett, '71; Musgrove, '73). Based on these investigations, several generalizations have been made concerning gene-teratogen interactions: (1) The frequency of a particular malformation, induced by a gene or teratogen alone, varies between different strains of the same species (Landauer, 1960). These differences are attributable to the action of many genes operating together rather than to the action of a single gene. (2) Teratogens, which induce phenotypic effects similar to mutant genes, may interact with these mutant genes to generate an enhanced effect on the embryo. (3) Modifying genes which affect the expression of a mutant gene may similarly affect teratogens which induce homologous defects."]},{"key":"dc:title","label":"Title","values":["The Interaction of a Mutant Gene, Paddlefoot (Pf), and a Teratogen, 6-Azauridine, on Limb Development in Two Inbred Strains of Mice."]}]}],"canonical_facts":{"dc:creator":["Coggin, Cherry Celeste"],"dc:description.abstract":["It is well known that mutant genes and environmental agents acting alone will induce developmental malformations. Within the past twenty-five years, more attention has been given to the interaction of the whole genome and specific mutant genes with either chemical or physical teratogens. Results of such studies have been reported in chickens, Drosophila and mammals (Landauer, '48, '60, '65; Goldschmidt and Piternick, '57; Barber, '59; Beck, '63, '64; Dagg, '66, '67, '72; Forsthoefel, '72, '75; Johnson, '70; Hamburgh et al., '70; Winfield and Bennett, '71; Musgrove, '73). Based on these investigations, several generalizations have been made concerning gene-teratogen interactions: (1) The frequency of a particular malformation, induced by a gene or teratogen alone, varies between different strains of the same species (Landauer, 1960). These differences are attributable to the action of many genes operating together rather than to the action of a single gene. (2) Teratogens, which induce phenotypic effects similar to mutant genes, may interact with these mutant genes to generate an enhanced effect on the embryo. (3) Modifying genes which affect the expression of a mutant gene may similarly affect teratogens which induce homologous defects."],"dc:identifier":["https://digitalcommons.library.uab.edu/etd-collection/7143"],"dc:subject":["Mammals","Drosophila","Gene-teratogen interactions","Physical teratogens","Genome"],"dc:title":["The Interaction of a Mutant Gene, Paddlefoot (Pf), and a Teratogen, 6-Azauridine, on Limb Development in Two Inbred Strains of Mice."],"thesis:degree_level":["Thesis"]},"updated_at":"2026-07-24T05:05:46Z"}