Cell Cycle Regulation and Cancer: The Emerging Role of KIAA1143

Proper regulation of the cell cycle checkpoints is essential for ensuring the accurate progression of each phase. When abnormalities occur in the proteins governing these checkpoints, diseases such as cancer frequently arise. These checkpoints include the G1/S transition, where cancer-associated mutations are most prevalent, the G2/M transition, and the spindle checkpoints. In this study, we characterize the novel gene KIAA1143 and explore its potential implications in cancer through its role in cell cycle checkpoints. Our study demonstrates that the KIAA1143 protein localizes to the nucleoplasm, specifically at the cytokinetic bridge, and exhibits peak expression during the S/G2 phase of the cell cycle. Many of KIAA1143’s identified transcription factors are associated with functions in the cell cycle. Data also reveals differential expression of KIAA1143 across cancer tissue types including Panc1 and HT29 cancer cell lines. Prognostic summary data highlights the overexpression of KIAA1143 posing favorable for patient survival in both renal and colon cancer. In conclusion, KIAA1143 is highly likely to play a role in the cell cycle, which is crucial in cancer development and diseases. However, additional data will be needed to confirm this. While KIAA contains multiple transcription factors that regulate other cell cycle proteins, our findings also highlight protein-protein interactions linked to cell cycle regulation. To gain a deeper understanding of the mechanisms of KIAA1143 and assess whether it functions as a cytokinetic checkpoint, CRISPR knockouts will be utilized to examine its mechanism within the same cancer cell types.

Discipline thesis:degree_discipline

Biology

Grantor

Texas State University

Year dc:date.issued

2025

Author dc:creator

• Lopez, Gisselle

Advisor dc:contributor.advisor

• Vargas, Micaela

Committee member dc:contributor.committeemember

• Rodriguez, David

• cytokinetic
• protein
• checkpoint
• KIAA
• mutations

Language dc:language.iso

en

Handle dc:identifier.uri

https://hdl.handle.net/10877/21644

OAI identifier oai:identifier

oai:digital.library.txst.edu:10877/21644