Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"cytokinetic"”.
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Bioinformatic identification and characterization of cytokinetic regulators in Mtb
… Significantly, SojMtb shows potential as a cytokinetic and dormancy regulator both by homology, morphology, and growth kinetic analysis. Overexpression of sojMtb attenuates growth and elicits filamentation characteristic of a disruption in early division, similar to Soj activity in other …
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Cell Cycle Regulation and Cancer: The Emerging Role of KIAA1143
… to the nucleoplasm, specifically at the cytokinetic bridge, and exhibits peak expression during the S/G2 phase of the cell cycle. Many of KIAA1143’s identified transcription factors are associated with functions in the cell cycle. Data also reveals differential expression of KIAA1143 …
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Interactions and Functions of the Ubiquitin Specific Protease 7 in Human Cells
… to the midbody, which were manifested in cytokinetic defects. Furthermore, cytokinetic defects associated with USP7 silencing were rescued by restoring FBXO38 or KIF20B. Therefore, I have identified novel roles for USP7 and FBXO38 in the regulation of cytokinesis.
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Regulation of The Escrt Function of Alix
… including MVB (multivesicular body) sorting, cytokinetic abscission and retroviral budding. Previous studies have demonstrated that ALIX involvement in these ESCRT-mediated processes requires ALIX interaction with the ESCRT-III component CHMP4 as well as a cargo protein. However, the native …
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Regulators of Bacterial Cell Division: Investigations of Min Oscillation and Ftsa Activity
… is essential for bacterial proliferation. The cytokinetic machinery in bacteria is termed the “divisome”. The divisome is a complex of proteins that forms a ring at midcell over dividing nucleoids. In order for daughter cells to form, the divisome must constrict. As constriction occurs, two new …
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Structure-function analysis of ZapC, an FtsZ-ring stabilizer, in Escherichia coli cytokinesis
… by the polymerization and constriction of a cytokinetic ring (Z ring) formed by FtsZ, a tubulin-like GTPase, at midcell. Division also involves the formation of a multi-protein complex at midcell known as the divisome. Several divisome proteins promote the assembly/disassembly processes of …
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The role of cell division during tissue morphogenesis
… abscission during de novo lumen formation. The cytokinetic bridge places at the center of the developing KV rosette, where it acts as a landmark for Rab11-mediated vesicle trafficking to bring polarity components such as CFTR to the site of future lumen formation. Next, the early zebrafish …
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EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
… also inhibits PLK1 expression which affects key cytokinetic pathway which ultimately reduced tumour forming capability of high PLK1 PC cells.
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FtsZ Protofilament Curvature is the Opposite of Tubulin Rings
… (pfs) that form the scaffold of the cytokinetic Z ring. These pfs can adopt a curved conformation forming a miniring or spiral tube 24 nm in diameter. Tubulin pfs also have a curved conformation, forming 42 nm tubulin rings. We have previously provided evidence that FtsZ generates a …
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Functional Investigation of Trypanosoma brucei Microtubule Associated Proteins and Their Role in Cellular Morphogenesis.
… of the parasite. RNAi ablation of GB4L causes a cytokinetic defect, as does depletion of TCP86 (another novel and trypanosomatid-specific MAP recently identified in the McKean laboratory). Electron microscopy was used to examine both the GB4L and TCP86 RNAi cell lines, demonstrating that the …
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Characterization of the interaction between FtsZ-ring stabilizer ZapC and the conserved protease ClpXP in E. coli cytokinesis
… to the process of division is the assembly of a cytokinetic ring-like structure, termed the Z-ring, formed by polymers of the essential tubulin-homolog FtsZ. Polymerization of FtsZ is regulated by a number of proteins that bind FtsZ and regulate its assembly/disassembly mechanisms. Despite being …
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Uncovering the Roles and Evolved Sequence Grammar of Hypervariable Intrinsically Disordered Proteins in Bacterial Cell Division
… the onset of cell division is the formation of a cytokinetic ring at the center of the cell. Cell division is a tightly controlled process that involves various regulatory factors that modulate the assembly of the cytokinetic ring. In rod-shaped bacteria, the ring is termed the Z-ring after the …
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We are what we eat : identifying a regulatory crosstalk between central carbon metabolism and cell division in bacteria
… division is initiated by the formation of the cytokinetic Z ring, made up of the tubulin-like protein FtsZ, at the cell centre (midcell). Research into the control of Z ring positioning in the well-studied rod-shaped bacteria has focused on two main regulatory systems, the Min system and …
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The Non-canonical Function and Regulation of TBK1 in the Cell Cycle
… cells, possibly due to several mitotic and cytokinetic defects seen in these knockout (KO) cells. We establish NAP1 as a cell cycle regulated protein which colocalizes with activated TBK1 on the centrosomes during mitosis. Furthermore, by performing an unbiased quantitative phosphoproteomics …
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From mice to men - astrocytes and neural progenitor cells in neural plasticity and regeneration
… during mitosis had been mutated, which show cytokinetic failure in fibroblasts and lens epithelial cells. We found that mutation of the serine sites phosphorylated in vimentin during mitosis leads to increased neuronal differentiation of neural progenitor cells, and suggest that this is a …
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Cytokine secretion in glioblastoma patients
… due to the marked dysregulation in their cytokinetic profile. Glial tumours seem to induce a Thi (stimulatory) to Th2-type (inhibitory) cytokine shift which further supports humoral immunity at the expense of cell-mediated immune responses, contributing to the inefficient anti-tumour …
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Adaptive lung growth following exposure to simulated high altitude
… growth (including biochemical, morphometric, cytokinetic and functional aspects) in rats from 4 to 7 weeks of age was studied. After 3 weeks of exposure, somatic growth was diminished in hypobaric hypoxic and normobarichypoxic animals, but lung growth was accelerated. All absolute biochemical …
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Differential regulation of cytokine secretion in multiple sclerosis
… of the present study were to characterize the cytokinetic profile of MS patients through investigating the secretion of the main pro and anti-inflammatory cytokines from peripheral blood mononuclear cells of MS patients compared to controls, and to investigate cytokine receptor expression …