Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"cytokinetic"”.
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Bioinformatic identification and characterization of cytokinetic regulators in Mtb
… Significantly, SojMtb shows potential as a cytokinetic and dormancy regulator both by homology, morphology, and growth kinetic analysis. Overexpression of sojMtb attenuates growth and elicits filamentation characteristic of a disruption in early division, similar to Soj activity in other …
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Cell Cycle Regulation and Cancer: The Emerging Role of KIAA1143
… to the nucleoplasm, specifically at the cytokinetic bridge, and exhibits peak expression during the S/G2 phase of the cell cycle. Many of KIAA1143’s identified transcription factors are associated with functions in the cell cycle. Data also reveals differential expression of KIAA1143 …
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Interactions and Functions of the Ubiquitin Specific Protease 7 in Human Cells
… to the midbody, which were manifested in cytokinetic defects. Furthermore, cytokinetic defects associated with USP7 silencing were rescued by restoring FBXO38 or KIF20B. Therefore, I have identified novel roles for USP7 and FBXO38 in the regulation of cytokinesis.
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Regulation of The Escrt Function of Alix
… including MVB (multivesicular body) sorting, cytokinetic abscission and retroviral budding. Previous studies have demonstrated that ALIX involvement in these ESCRT-mediated processes requires ALIX interaction with the ESCRT-III component CHMP4 as well as a cargo protein. However, the native …
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Regulators of Bacterial Cell Division: Investigations of Min Oscillation and Ftsa Activity
… is essential for bacterial proliferation. The cytokinetic machinery in bacteria is termed the “divisome”. The divisome is a complex of proteins that forms a ring at midcell over dividing nucleoids. In order for daughter cells to form, the divisome must constrict. As constriction occurs, two new …
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Structure-function analysis of ZapC, an FtsZ-ring stabilizer, in Escherichia coli cytokinesis
… by the polymerization and constriction of a cytokinetic ring (Z ring) formed by FtsZ, a tubulin-like GTPase, at midcell. Division also involves the formation of a multi-protein complex at midcell known as the divisome. Several divisome proteins promote the assembly/disassembly processes of …
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The role of cell division during tissue morphogenesis
… abscission during de novo lumen formation. The cytokinetic bridge places at the center of the developing KV rosette, where it acts as a landmark for Rab11-mediated vesicle trafficking to bring polarity components such as CFTR to the site of future lumen formation. Next, the early zebrafish …
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EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
… also inhibits PLK1 expression which affects key cytokinetic pathway which ultimately reduced tumour forming capability of high PLK1 PC cells.
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Functional Investigation of Trypanosoma brucei Microtubule Associated Proteins and Their Role in Cellular Morphogenesis.
… of the parasite. RNAi ablation of GB4L causes a cytokinetic defect, as does depletion of TCP86 (another novel and trypanosomatid-specific MAP recently identified in the McKean laboratory). Electron microscopy was used to examine both the GB4L and TCP86 RNAi cell lines, demonstrating that the …
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FtsZ Protofilament Curvature is the Opposite of Tubulin Rings
… (pfs) that form the scaffold of the cytokinetic Z ring. These pfs can adopt a curved conformation forming a miniring or spiral tube 24 nm in diameter. Tubulin pfs also have a curved conformation, forming 42 nm tubulin rings. We have previously provided evidence that FtsZ generates a …
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Characterization of the interaction between FtsZ-ring stabilizer ZapC and the conserved protease ClpXP in E. coli cytokinesis
… to the process of division is the assembly of a cytokinetic ring-like structure, termed the Z-ring, formed by polymers of the essential tubulin-homolog FtsZ. Polymerization of FtsZ is regulated by a number of proteins that bind FtsZ and regulate its assembly/disassembly mechanisms. Despite being …
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Uncovering the Roles and Evolved Sequence Grammar of Hypervariable Intrinsically Disordered Proteins in Bacterial Cell Division
… the onset of cell division is the formation of a cytokinetic ring at the center of the cell. Cell division is a tightly controlled process that involves various regulatory factors that modulate the assembly of the cytokinetic ring. In rod-shaped bacteria, the ring is termed the Z-ring after the …
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We are what we eat : identifying a regulatory crosstalk between central carbon metabolism and cell division in bacteria
… division is initiated by the formation of the cytokinetic Z ring, made up of the tubulin-like protein FtsZ, at the cell centre (midcell). Research into the control of Z ring positioning in the well-studied rod-shaped bacteria has focused on two main regulatory systems, the Min system and …
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The Non-canonical Function and Regulation of TBK1 in the Cell Cycle
… cells, possibly due to several mitotic and cytokinetic defects seen in these knockout (KO) cells. We establish NAP1 as a cell cycle regulated protein which colocalizes with activated TBK1 on the centrosomes during mitosis. Furthermore, by performing an unbiased quantitative phosphoproteomics …
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Cytokine secretion in glioblastoma patients
… due to the marked dysregulation in their cytokinetic profile. Glial tumours seem to induce a Thi (stimulatory) to Th2-type (inhibitory) cytokine shift which further supports humoral immunity at the expense of cell-mediated immune responses, contributing to the inefficient anti-tumour …
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Adaptive lung growth following exposure to simulated high altitude
… growth (including biochemical, morphometric, cytokinetic and functional aspects) in rats from 4 to 7 weeks of age was studied. After 3 weeks of exposure, somatic growth was diminished in hypobaric hypoxic and normobarichypoxic animals, but lung growth was accelerated. All absolute biochemical …
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Differential regulation of cytokine secretion in multiple sclerosis
… of the present study were to characterize the cytokinetic profile of MS patients through investigating the secretion of the main pro and anti-inflammatory cytokines from peripheral blood mononuclear cells of MS patients compared to controls, and to investigate cytokine receptor expression …