Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"cell cycle checkpoints"”.
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Cell cycle checkpoints and checkpoint kinases in the apicomplexan parasites Plasmodium and Toxoplasma
… issue. DNA repair mechanisms and particularly cell cycle checkpoint mechanisms in *P. falciparum* are not well characterised. A greater understanding of these is required, especially as artemisinin- resistant parasites have a dormancy phenotype that resembles a cell cycle checkpoint. …
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Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions
… tumors, that functions in mitotic entry after cellular stress, centrosome maturation, mitotic spindle control, and cytokinesis, which are all disregulated in cancer cells. To study the role of Polo-like kinases we took advantage of the recent discovery that the polo-box domain of Polo-like …
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Cell Cycle Regulation and Cancer: The Emerging Role of KIAA1143
Proper regulation of the cell cycle checkpoints is essential for ensuring the accurate progression of each phase. When abnormalities occur in the proteins governing these checkpoints, diseases such as cancer frequently arise. These checkpoints include the G1/S transition, where cancer-associated …
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Roles for C-ABL and P53 in bone homeostasis and DNA damage response
… kinase, acts at a novel step that affects most cellular events in DNA damage response. c-Abl-/- MEFs showed defects in nuclear foci assembly of adaptor proteins such as TopBP1, Brca1, activation of Chk2 and Chk1, phosphorylation of p53 at Ser15 and induction of p53 target genes, cell cycle …
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AGO2 in overexpression exhibits oncogenic functions KrasG̳1̳2̳D̳ -associated mouse tumor models
Cancer is a disease of normal healthy cells that have accumulated genetic aberrations that contribute to uncontrolled cell divisions. Generally, cancer cells have acquired gain of function mutations in oncogenes that positively promote cell proliferation and growth. Simultaneously, mutations in …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… (UV). UV-induced DNA damage activates cell cycle checkpoints through a mechanism involving degradation of the cyclin dependent kinase activators, the cell division cycle 25 (CDC25) phosphatases, and also activates Erbb family members indirectly through reactive oxygen species …
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Disruption of UHRF1 expression in chicken DT40 cells
… expression in a wide range of different cancer cells, and its ability to facilitate the crosstalk between DNA methylation and histone modification, thereby driving the occurrence of cancer and ensuring the inheritance of accurate epigenomic information to descendent cells. Depletion of UHRF1 …
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Consequences of partial chromosome re-replication in mammalian cells
To prevent re-replication of DNA in a single cell cycle, the licensing of<br/>replication origins by Mcm2-7 is prevented during S and G2 phases. Metazoans<br/>achieve this by cell cycle regulated proteolysis of the essential licensing factor<br/>Cdt1 and formation of an inhibitory heterohexameric …
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Circadian Control of Cell Cycle Progression
Tumorigenesis is the result of uncontrolled cell growth due to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint …
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Developing 1,2,3,4-tetrahydro-5H-aryl[1,4]diazepin-5-ones and Related Scaffolds as Poly-(ADP-ribosyl) Polymerase (PARP) Inhibitors and Exploring Their Targeted Polypharmacology with Kinases
… inhibition, including PI3K/AKT/mTor pathway, and cell-cycle checkpoints (such as CDKs, CHK, and Wee) are being tested. In this context, the synthetic lethality of cyclin-dependent kinase 1 (CDK1) and PARP1 is known. Evaluation of PARP1 and CDK1 pharmacophores led to the development of the …
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Mathematical Modeling Reveals That G2/M Checkpoint Override
<p>Cell cycle checkpoints determine whether cells meet requirements to progress through the next stage. In response to DNA damage, how cells activate checkpoints have been well studied, but little is known about checkpoint deactivation (recovery), which directly impacts on cell fate. In tumor …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
<p>Cell cycle checkpoints determine whether cells meet requirements to progress through the next stage. In response to DNA damage, how cells activate checkpoints have been well studied, but little is known about checkpoint deactivation (recovery), which directly impacts on cell fate. In tumor …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
<p>Cell cycle checkpoints determine whether cells meet requirements to progress through the next stage. In response to DNA damage, how cells activate checkpoints have been well studied, but little is known about checkpoint deactivation (recovery), which directly impacts on cell fate. In tumor …
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Genetics of Stress-Induced Responses in Drosophila
… conserved process responsible for elimination of cells during normal development and after cellular damage. Apical caspases that initiate caspase cascades are stimulated upon interaction with adaptor molecules. The Drosophila adaptor protein Dark, a homolog of nematode Ced-4 and mammalian Apaf-1, …
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Atm Signaling to Tsc2: Mechanisms and Implications For Cancer Therapy
… mutated (ATM) is a critical component of the cellular response to DNA damage, where it acts as a damage sensor, and signals to a large network of proteins which execute the important tasks involved in responding to the damage, namely inducing cell cycle checkpoints, inducing DNA repair, …
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The Role of CDC25A in Ultraviolet-induced Nonmelanoma Skin Tumorigenesis
Cell division cycle 25A (CDC25A) is a dual-specificity phosphatase that removes inhibitory phosphate groups from cyclin-dependent kinases, allowing cell cycle progression. Activation of cell cycle checkpoints following DNA damage can result in degradation of CDC25A, leading to cell cycle arrest. …
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Genome-Wide Profiling Unveils Criticial Functions of P53 In Human Embryonic Stem Cells
<p>Embryonic stem cells (ESCs) possess two unique characteristics: infinite self-renewal and the potential to differentiate into almost every cell type (pluripotency). Recently, global expression analyses of metastatic breast and lung cancers revealed an ESC-like expression program or signature, …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… and have been described to have defects in the T cell maturation. By studying the apoptosis response of NOD lymphocytes (which activates similar cell-cycle checkpoints and apoptosis pathways as during thymocyte maturation) we showed differential expression of the miRNA-34a/b/c gene family, miR-125 …
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Elucidating the roles of the diguanylate cyclases CelR and avmA in attachment and cellulose synthesis with the response regulator divK in Agrobacterium tumefaciens
… in plants, physically interacts with plant cells to remain anchored within the nutrient-rich rhizosphere. Part of this interaction involves the production of cellulose fibrils by the bacteria, leading to the aggregation of the cells to each other as well as to the plant surface. While this …
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