EVALUATION OF THE COMBINATION OF PROSTANOIDS AND FEMALE SEX HORMONES AS INFLAMMATION BIOMARKERS AND THEIR IMPLICATION ON HYPERTENSION

Hypertension is a chronic medical condition, and a primary contributor to severe cardiovascular disease. It can increase mortality risk. Studies have found that a low-grade inflammation is involved in the development of hypertension. In addition, men have been found to have a higher risk of hypertension than age-matched women, while women have an increased risk of hypertension after menopause. Female sex hormones are considered to play a protective role in the development and progression of hypertension. Prostanoids are inflammatory mediators, and have important physiological roles on promoting or suppressing inflammation. Studying the combined roles of these two biochemical families in disease development will be helpful to understand the balance between a self-protective effect and inflammatory response in hypertension, and find effective biomarkers to predict the progression of hypertension. In my study, a reversed phase high performance liquid chromatography is used to develop the

Grantor dc:publisher

Temple University. Libraries

Year dc:date.issued

2015

Author dc:creator

• Wei, Guoxiu

Advisor dc:contributor.advisor

• Varnum, Susan A.

Committee members dc:contributor.committeemember

• Varnum, Susan A.
• Wunder, Stephanie L.
• Zdilla, Michael J., 1978-
• Shi, Justin Y.

• Chemistry
• Hypertension
• Prostanoids
• Quantitative structure-retention relationship
• Sex hormones

Statement dc:rights

• IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

eng

Dc Identifier Other

958156823

OAI identifier oai:identifier

oai:scholarshare.temple.edu:20.500.12613/4025