Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"Low-grade inflammation"”.
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Acute, Low-Grade Inflammation elevates White Matter Sensitivity to Ischaemia
… highly prevalent neurological diseases. Acute, low-grade inflammation, often resulting from peripheral infection, has emerged as a risk factor. White matter axons, and their supporting glia, are susceptible to both ischaemic and neuroinflammatory injury. The mechanisms behind ischaemic injury in …
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The Metabolic Effects of Low Grade Inflammation on Postprandial Metabolism Following a High Fat Meal
Inflammation is a central feature of various metabolic diseases including obesity and type-II diabetes. For this study, we hypothesized postprandial metabolism following an acute, high fat (HF) meal to be impaired in mice pre-injected with an inflammatory agonist. To this end, C57BL/6J mice were …
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Super Low Dose Endotoxin Exacerbates Low Grade Inflammation through Modulating Cell Stress and Decreasing Cellular Homeostatic Protein Expression
The establishment of non-resolving inflammation underlies the pathogenesis of chronic inflammatory diseases in humans. Super low dose (SLD) endotoxin has been associated with exacerbating inflammation and the pathogenesis of chronic inflammatory diseases. However, the underlying molecular …
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The effect of single nucleotide polymorphisms of oxidative stress genes and low grade inflammation upon pulse wave contour analysis, a useful non invasive, intermediate vascular phenotype.
… both biochemical markers of oxidative stress and low grade chronic inflammation as well as a non invasive vascular phenotype, pulse wave analysis. This thesis reports a series of studies (utilising the techniques described in chapter 2) which aimed to ascertain:- The reproducibility of pulse …
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Proposed in vitro model of neutrophil swarming in a chronic, low-level inflammatory state
Chronic, low-grade inflammation is an underlying condition across a globally increasing number of debilitating diseases. These diseases include obesity, atherosclerosis, and diabetes and their resultant low-grade inflammation can be effectivity modeled with low dose stimulants such as …
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Epigenomic and Transcriptomic Changes in the Onset of Disease
Current sequencing technologies allows researchers unprecedented insight into our biology, and how these biological mechanisms can become distorted and lead to disease. These aberrant mechanisms can be brought about by many causes, but some occur as a result of genetic mutations or external factors …
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Resolvin E1 actions on polymorphonuclear neutrophils in diabetes
… molecules are characteristic to T2DM-associated low-grade inflammation. However, the mechanisms by which chronic hyperglycemia leads to leukocyte activation are not fully understood. [TRUNCATED]
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Impact of saskatoon berry powder on metabolism and gut microbiota in diet-induced insulin resistant mice
… Metabolic syndromes are characterized by low-grade inflammation and insulin resistance, and are usually accompanied with alteration in the gut microbiota profile. Evidence in recent decades shows that the gut microbiota plays a significant role in the development of metabolic syndromes, …
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Systems and Comparative Analyses of Monocyte Dynamics Based Upon Single Cell Sequencing Data
… expression of genes associated with pathogenic inflammation and immune suppression.. In contrast, super-low-dose LPS led to a state of low-grade inflammation, characterized by enhanced chemotaxis; immune-enhancement; and adhesion.. Pseudo-time analysis revealed a potential bifurcation of …
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Insulin resistance in cancer cachexia and metabolic syndrome
… common issues such as insulin resistance and low-grade inflammation. In these scenarios, tissue macrophages act as key players, due to their capacity to produce and release inflammatory mediators. One of the main features of MetS is hyperinsulinemia, which is generally associated with an …
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Berries in Prevention of Metabolic Disease – focus on obesity, diabetes and gut microbiota
… reduced body weight gain, insulin resistance, low-grade inflammation and hepatic lipid accumulation in C57BL/6J mice fed a high-fat diet. Supplementation with raspberries, crowberries, blackberries or prunes had no or small effects, whereas açai berries promoted development of obesity and fatty …
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Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
Sepsis and chronic inflammation remain unresolved clinical challenges due to immune dysregulation. Innate immune cells, particularly monocytes, are key regulators of inflammation and its resolution. However, unbalanced or prolonged stimulation can drive these cells into dysfunctional states. These …
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EVALUATION OF THE COMBINATION OF PROSTANOIDS AND FEMALE SEX HORMONES AS INFLAMMATION BIOMARKERS AND THEIR IMPLICATION ON HYPERTENSION
… mortality risk. Studies have found that a low-grade inflammation is involved in the development of hypertension. In addition, men have been found to have a higher risk of hypertension than age-matched women, while women have an increased risk of hypertension after menopause. Female sex …
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Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease
… between PTB and the development of chronic airflow obstruction (CAO). The nature of this association and mechanisms responsible for CAO has not been previously studied, but likely includes: airway narrowing (from bronchiolitis, bronchiectasis or persistent low-grade inflammation associated with …
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Monitoring Arthritis - Biochemical, Metodological and Clinical Aspects
… knee OA. In paper II, we studied the presence of low-grade systemic inflammation in individuals with chronic knee pain with and without radiographically verified knee OA by measuring high-sensitivity(hs)CRP. We found that low-grade inflammation is a feature of knee OA especially in individuals …
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… phenotype, which is characterized by chronic low-grade inflammation, insulin resistance, and ectopic lipid accumulation. Research has implicated synthetic (i.e., Bisdehydrodoisynolic acid, BDDA) and natural (i.e., genistein and daidzein) xenoestrogens in the protection against obesity-related …
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The inflammatory potential of the diet of 1-9-year-old children living in two urbanized and economically active provinces in South Africa
… abundance of research suggests that “sustained inflammation is the common denominator of all chronic disease” (Noland, 2017). Low-grade inflammation is characterized by raised concentrations of inflammatory biomarkers without any overt symptoms (Bonaccio et al., 2017). To date, many studies have …
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Research on the Participation of Humoral Factors of Congenital Immunity in the Pathogenesis of Activated Osteoarthritis // Изследване участието на хуморалните фактори на вродения имунитет в патогенезата на активираната остеоартроза
… argue for the application of drugs affecting low-grade inflammation as a disease-modifying treatment model and confirm the need for therapeutic control of inflammation in the arthritic joint at an early radiological stage of the disease.
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A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease
… disease features, biomarkers of chronic low-grade inflammation and type 2 diabetes; (3) to explore whether central adiposity indices provide additional information regarding disease and risk status, compared to general adiposity characterised by body mass index (BMI); (4) to investigate …
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