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Showing 1 to 16 of 16 for “"Prostanoids"”.
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EVALUATION OF THE COMBINATION OF PROSTANOIDS AND FEMALE SEX HORMONES AS INFLAMMATION BIOMARKERS AND THEIR IMPLICATION ON HYPERTENSION
… the development and progression of hypertension. Prostanoids are inflammatory mediators, and have important physiological roles on promoting or suppressing inflammation. Studying the combined roles of these two biochemical families in disease development will be helpful to understand the balance …
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Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
… also be induced by cAMP. This is interesting as prostanoids, a type of drug used in the treatment of PAH due to its vasodilator effects and the only type to show any efficacy improving the life expectancy of PAH patients, acts by mobilising cAMP. Thus, prostanoid stimulation of cAMP could …
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EVALUATION OF THE OXIDATIVE METABOLITES OF ARACHIDONIC ACID AND THEIR IMPLICATION IN THE PROGRESSION OF INFLAMMATORY DISEASES: HYPERTENSION AND RHEUMATOID ARTHRITIS
… applied to study the effect of acute exercise on prostanoids in hypertensive African American subjects. It was our theory that urinary 6-keto PGF1&alpha and 11-dehydro TXB2 can be used to assess the role of exercise in hypertension. Moreover, we assume that 8-iso PGF2 levels can be used as an …
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The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
… PGF2¿ and Thromboxane A2 (TXA2), also termed prostanoids, are synthesised and deactivated to 15-keto PGE2, J2 metabolites, 6-keto-PGF1¿, 15-keto PGF2¿ and TXB2 respectively. However, not all metabolites have been analysed simultaneously within the same tissue. The primary objective of this …
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Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
… mediators in the liver. Among them there are prostanoids (prostaglandin (PG) E2 and thromboxane (Tx) A2), cytokines (e.g. interleukin (IL)-1,-6, -10, tumor necrosis factor (TNF) α) and inorganic mediators like nitric oxide (NO). Macrophages-derived products play opposing roles in the …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… leukotrienes, epoxyeicosatrienoic acids, and prostanoids) to activate adaptive immunity. Leukotrienes (LTs), an eicosanoids subset, are produced from arachidonic acid via 5- lipoxygenase metabolism, resulting in LTB4 and cysteinyl LTs (cysLTs; LTC4, LTD4 and LTE4). CysLTs, which are …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… Eicosanoids (epoxyeicosatreinoic acids, prostanoids and leukotrienes) are generated from metabolites of 20-carbon chained polyunsaturated fatty acids and arachidonic acid. Leukotrienes (LTs) are generated from 5- lipoxygenase-metabolism of arachidonic acid to LTB4 and cysteinyl LTs …
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The Acute And Chronic Effects Of Resveratrol On Renal Function And Blood Pressure
… influenced by COX metabolism and vasodilatory prostanoids. We found with continuous intravenous resveratrol infusion induced significant renal vasodilation while not altering either glomerular filtration rate or blood pressure in normal rats. Resveratrol infusion produced significant …
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Synthesis of anticancer agents: 15-deoxy-15-fluoro-Δ12-prostaglandin J3 and gukulenin monomeric units
… production of various natural and designed prostanoids, and the development of several landmark synthetic methodologies. Among the large family of PGs, a subclass known as the alkylidene-cyclopentenone prostaglandins (acyPGs) has been increasingly recognized for their prominent anticancer …
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Bioactive Lipids in Nociception
… acetaminophen is able to reduce the content of prostanoids in brain and kidney, but this effect is independent of FAAH. While ibuprofen produces a similar reduction as acetaminophen of the PGE2 level in brain, only acetaminophen displays antinociceptive activity in animal tests of acute …
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The effect of eicosapentaenoic acid on brain and platelet produced bioactive lipid mediators. The effect of eicosapentaenoic acid, docosapentaenoic acid and other polyunsaturated fatty acids on the eicosanoids and endocannabinoids produced by rat brain and human platelets using electrospray ionisation tandem mass spectrometry-based analysis.
… AA can be converted by cyclooxygenase (COX) to prostanoids and by lipoxygenase (LOX) to hydroxy fatty acids. PUFA can also be converted to ethanolamides in the brain. These mediators are involved in physiological and pathological processes in many bodily systems. The purpose of this study was to …
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Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… an ACE inhibitor, we found that manipulation of prostanoids is important. Indomethacin, (a cyclooxygenase inhibitor) (n=8) blocked relaxin’s vasodilatory action. Manipulation of the cAMP second messenger system, with milrinone, (a cAMP phosphodiesterase inhibitor) (n=6) is also important as …
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The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
… enzyme and enhanced synthesis of prostanoids, such as prostaglandin E2, in cervical carcinomas. Prostaglandin E2 mediates its effects by interacting with one of four receptors termed EPI-4. Expression and signalling of EP receptors, including EP4, are elevated in cervical …
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A Combined Computational Strategy of Sequence and Structural Analysis Predicts the Existence of a Functional Eicosanoid Pathway in <i>Drosophila melanogaster</i>
… players in human health and disease. Mammalian prostanoids and related lipid mediators perform varied functions in different tissues and organs. Synthesized through the oxygenation of C20 polyunsaturated fatty acids, mammalian eicosanoids are both pro- and anti-inflammatory. The physiological …
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Genetic Polymorphism of Prostanoid Receptors, CRTH2 and TBXA2R in Aspirin Hypersensitivity
… AIA and AIAU in an association with prostanoids receptor CRTH2 and TBXA2R. The human CRTH2 gene (official name GPR44) encodes a G protein-coupled chemoattractant receptor molecule which is expressed on Th2 cells including other allergy related cells like eosinophils, basophils and …
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Isolation and Characterization of Regulatory Peptides from Two Tetraploid Species, the Pallid Sturgeon, Scaphirhynchus albus, and the African Clawed Frog, Xenopus laevis
… (10 pM), indicating the involvement of prostanoids. Porcine GRP, which differs from A laevis GRP-1 by 13 amino acids and contains two deletions in the N-terminal region, produced identical responses in these tissues, which demonstrates the importance of the highly conserved COOH-terminal …