Remote controlled drug release in drug-eluting stents

Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome.

Name dc:type.qualificationname

msc

Level dc:type.qualificationlevel

masters-pg

Grantor dc:publisher.institution

University of Strathclyde

Year dc:date.issued

2013

Author dc:creator

• Al-Nasser, Noor

DOI

10.48730/nkb0-cy10

Identifier

T13669

OAI identifier oai:identifier

oai:strathclyde:kd17cs92v