{"id":{"repo_id":"strathclyde","oai_identifier":"oai:strathclyde:kd17cs92v"},"canonical_url":"https://search.dev.ndltd.org/etd/strathclyde/oai:strathclyde:kd17cs92v","repository":{"repo_id":"strathclyde","name":"University of Strathclyde","base_url":"https://stax.strath.ac.uk/catalog/oai"},"display":{"title":"Remote controlled drug release in drug-eluting stents","abstract":"Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome.","abstract_html":"Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome.","abstract_has_math":false,"creators":["Al-Nasser, Noor"],"institution":"University of Strathclyde","degree_name":"msc","degree_level":"masters-pg","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-24T04:46:21Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["10.48730/nkb0-cy10"],"render_values":[{"text":"10.48730/nkb0-cy10","href":"https://doi.org/10.48730/nkb0-cy10","code":true}]},{"key":"dc:identifier","label":"Identifier","values":["T13669"],"render_values":[{"text":"T13669","href":null,"code":true}]}]},"links":{"outbound_url":"https://stax.strath.ac.uk/concern/theses/kd17cs92v","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Al-Nasser, Noor"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Biomedical Engineering"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Strathclyde"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["masters-pg"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["msc"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["T13669"]},{"key":"dc:identifier.doi","label":"DOI","values":["10.48730/nkb0-cy10"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://stax.strath.ac.uk/concern/theses/kd17cs92v"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This thesis was previously held under moratorium from 17th March 2014 until 17th March 2018.","Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome."]},{"key":"dc:description.abstract","label":"Abstract","values":["Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome."]},{"key":"dc:title","label":"Title","values":["Remote controlled drug release in drug-eluting stents"]}]}],"canonical_facts":{"dc:creator":["Al-Nasser, Noor"],"dc:date":["2013"],"dc:date.issued":["2013"],"dc:description":["This thesis was previously held under moratorium from 17th March 2014 until 17th March 2018.","Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome."],"dc:description.abstract":["Coronary artery disease is one of the most predominant types of heart diseases present in the 21st century, attributing to a staggering 7.2 million deaths annually across the globe. After implantation of currently the most successful coronary intervention, drug-eluting stents are placed within obstructive arteries to restore blood flow to the heart and reverse life-threatening consequences. However, it is still plagued by the resurrection of artery occlusion, resulted by stent-induced restenosis.This battling and persistent problem is of complex aetiology, even with the incorporation of anti-proliferative drugs. One of the key flaws resulting in the restenosis is denying the arterial wall time to heal after implantation due to the sequential drug release. Introducing a novel smart drug delivery system onto stents can enable the release of drug locally in a controlled manner by means of an external ultrasonic stimulus. This ultrasonic-triggered drug release can be tailored to the needs of individuals and controlled within the hands of the cardiologist, to maximise drug efficacy and patient outcome."],"dc:identifier":["T13669"],"dc:identifier.doi":["10.48730/nkb0-cy10"],"dc:identifier.uri":["https://stax.strath.ac.uk/concern/theses/kd17cs92v"],"dc:publisher.department":["Department of Biomedical Engineering"],"dc:publisher.institution":["University of Strathclyde"],"dc:title":["Remote controlled drug release in drug-eluting stents"],"dc:type.qualificationlevel":["masters-pg"],"dc:type.qualificationname":["msc"]},"updated_at":"2026-07-24T04:46:21Z"}