Pharmacocinétique comparative des curcuminoïdes avec ou sans oméga-3 : une étude en chassé-croisé randomisée

In the last years, there is a growing interest around the turmeric spice in the media and in the older population. Turmeric contains curcuminoids which are the active compounds and lipophilic, hence to low solubility in water and low bioavailability in the human plasma. To circumvent this issue, a natural product developed by Biodroga Nutraceuticals combined curcuminoids with omega-3 fatty acids (OM3) esterified in monoglycerides (MAG). MAG are lipophilic with a hydrophilic polar head that confers emulsification properties. The hypothesis was that MAG-OM3 will improve the absorption and bioavailability of curcuminoids compared to other formulations of curcuminoids. The objective was to perform a 24 h pharmacokinetics in humans receiving a single dose of curcuminoids formulated by three different means, and to compare their plasma curcuminoids concentration. The study was a triple-blind, randomized, crossover study where participants tested three formulations: 400 mg of curcuminoids powder extract, 400 mg of curcuminoids in rice oil and 400 mg of curcuminoids with 1 g MAG-OM3. Sixteen males and fifteen females consumed a single oral dose of one of the three formulations in a random order and blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 8, 10 and 24 h post dose intake. Between each treatment, there was a washout period of a minimum of 7 days. Plasma samples were analyzed by ultra high-performance liquid chromatography with a triple quadrupole mass spectrometer (UPLC-MS/MS). Participants mean age was 27.6 ± 6.0 years old and they had an average body mass index of 25.1 ± 3.8 kg/m2. Twenty-four hours after a single dose intake, the total plasma curcuminoids area under the curve (AUC) reached 166.8 ± 17.8 ng/ml*h, 134.0 ± 12.7 ng/ml*h and 163.1 ± 15.3 ng/ml*h when curcuminoids were provided with MAG-OM3, with rice oil or in powder, respectively. The 0-6h AUC ranged between 37.6 and 53.3 ng/ml*h of total plasma curcuminoids. The Cmax of total curcuminoids reached between 11.9-17.7 ng/ml at around 4h (Tmax). One-hour post-dose, the curcuminoids plasma concentration was 40% higher in participants consuming the MAG-OM3 supplement (13,6 ± 1,8 ng/ml) compared to when combined with rice oil (8,2 ± 1,0 ng/ml) or in powder (4,1 ± 0,9 ng/ml). Thus, in a young population, plasma curcuminoids 24h pharmacokinetics and its increase shortly after the single dose intake was higher when provided with MAG-OM3 than when provided with rice oil.

Name thesis:degree_name

M. Sc.

Level thesis:degree_level

Maîtrise

Discipline thesis:degree_discipline

Physiologie

Grantor dc:publisher

Université de Sherbrooke

Year dc:date.issued

2022

Author dc:creator

• Cisneros Aguilera, Ester

Advisor dc:contributor.advisor

• Plourde, Mélanie

• Curcuminoïdes
• Curcumine
• Monoglycérides oméga-3
• Absorption
• Pharmacocinétique
• Curcuminoids
• Curcumin
• Monoglycerides omega-3
• Pharmacokinetics

Language dc:language.iso

fr, en

Handle dc:identifier.uri

http://hdl.handle.net/11143/21342

OAI identifier oai:identifier

oai:usherbrooke.scholaris.ca:11143/21342