Synthesis and Characterization of Carbon Monoxide Producers Bipyridine Flavonolate Palladium(II) and Platinum(II) Complexes: Potential Anti-Cancer Agents

<p>Novel designed metal ligand complexes as prodrugs are useful in the effort to find more effective and selective anti-cancer<strong> </strong>treatments. Carbon monoxide, CO, is known to induce mitochondrial collapse in cancer cells. Herein is described the synthesis of seven novel bipyridine flavonolate palladium(II) and platinum(II) complexes with the property of releasing carbon monoxide, and their characterization with FTIR, UV-Vis, fluorescence, NMR, and ESI mass spectra. Their ability to release carbon monoxide was investigated through oxygenation reaction under various conditions of temperature and light irradiation. The nitroxygenation reaction of the palladium complexes was also studied with nitrosyl hydride, HNO, generated in situ from Angeli’s salt. Deoxymyoglobin was used to trap CO released from the complexes, and the reaction was monitored spectroscopically. The spectra showed that oxygenation reaction did not produce CO in the palladium complexes but did in the platinum complexes with irradiation, whereas nitroxygenation reaction did in the palladium complexes.</p>

Name thesis:degree_name

Master of Science - Natural Sciences

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Chemistry and Biochemistry

Year dc:date.available

2020

Author dc:creator

• Whitfield, Sarah

Contributors dc:contributor

• Xiaozhen Han, Ph.D.
• J. Brannon Gary, Ph.D.
• Michele Harris, Ph.D.

• carbon monoxide
• flavonol
• transition metal
• anti-cancer
• light-activated
• Inorganic Chemistry

Repository record dc:identifier

https://scholarworks.sfasu.edu/etds/291

OAI identifier oai:identifier

oai:scholarworks.sfasu.edu:etds-1329