Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 587 for “"anti-cancer"”.
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Computational studies of anti-cancer Aurein peptides
Submitted in fulfilment of the requirements of the Degree of Master of Technology: Chemistry, Durban University of Technology, Durban, South Africa, 2014.
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Development of exosome-based anti-cancer therapeutics
… (HCC) exosomes are found to be responsible for cancer progression, metastasis, and angiogenesis via cellular communications. However, studying cancer derived exosomes in vitro is limited, due to the way cell lines are grown in medium supplemented with foetal bovine serum (FBS) that contains …
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Functional Interrogation Of Anti-Cancer Drug Resistance
… to achieve a precise map of each individual cancer’s genomic lesions, providing insights into the best strategies for treatment. However, these approaches will be undermined by cancer’s ability to resist upfront target inhibition (intrinsic resistance) as well as, in cases where tumors are …
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Anti – Cancer effects of Momordica charantia in- vitro
… have been used extensively for the treatment of cancers throughout the world. In many parts of the world, especially in poor countries, this may be the only form of cancer therapy. Much research has been focused on the scientific evaluation of traditional anti-cancer drugs from the tropical …
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New Carbohydrate-Based Anti-Cancer And Anti-Bacterial Vaccines
… unique carbohydrates expressed on the surface of cancer, bacterial, viral and fungal cells are excellent target antigens for the design of therapeutic or preventive vaccines. However, as antigens carbohydrates have problems. First, carbohydrates usually have low immunogenicity. Second, even if …
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SERS & efficacy assessment of anti-cancer drug-nanoparticle conjugates
Non-small cell lung cancer (NSCLC) is the result of tumour development from genetically-mutated epithelial cells lining the surface of the lung. Clinical response to treatments is generally gauged by comparing tumour sizes pre- and posttreatment on computerised tomography. If no response is …
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Synthesis and biological evaluation of potential anti-cancer agents
… used to prepare a large number of compounds of anti-cancer screening. A library of caffeic acid derivatives has been prepared by the Knoevenagel condensation of aldehyde and active methylene reagents. These products have been screened against two murine adenocarcinoma cell lines (MAC) which are …
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Inflammation enhanced colon cancer & natural anti-cancer plant compounds
… associated with an increased risk for colorectal cancer through mechanisms that are not well understood. Isothiocyanates, which are the bioactive components in broccoli and other cruciferous vegetables, have been shown to suppress COX-2 and IL-6 production from inflammation. The polyacetylene …
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Studies on the anti-cancer potential of sesquiterpene lactone parthenolide
… This compound has long been known to have potent anti-inflammatory properties. However, its anti-cancer properties are less studied. Thus, the main objective of this study is to systematically investigate the anti-cancer properties of parthenolide in vitro and in vivo. The results from current …
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Stable Polymer Micelle Systems as Anti-cancer Drug Delivery Carriers
… sequester 1,6-diphenylhexatriene (DPH) and the anti-cancer drug doxorubicin (DOX). Nanoparticles with 0.5 wt% BAC stored at room temperature in 0.002 mg/ml solutions were stable for up to two weeks. Poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-lactaten) …
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Quantitative pharmacoproteomics investigation of anti-cancer drugs in mouse. Development and optimisation of proteomics workflows for evaluating the effect of anti-cancer drugs on mouse liver
Minimizing anti-cancer drug toxicity is a major challenge for the pharmaceutical industry. Toxicity is most frequently due to either the direct interaction of the drug on previously unidentified targets or its conversion to metabolites by drug metabolizing enzymes (e.g. CYP450 enzymes) that cause …
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Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment
… was named as Spa310. In this dissertation, the anti-cancer functions and mechanisms of Spa310 were studied. The synthesized Spa310 peptide was able to inhibit the kinase activities of Cdk2/Cyclin E/A complexes. In vitro kinase assays showed the inhibition occurred in a dose-dependent manner. The …
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Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
… diagnosed at early stage. According to American cancer society pancreatic cancer, it has lowest survival rate in all cancer types, with less than 6% five year survival rate. Surgical resection is only possible for 20% of diagnosed cases and current chemotherapy has only 15% response rate. Even …
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
… signalling pathways is often associated with cancer. TheRhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancersand has also been shown to be involved in metastasis and apoptosis. ROCK is inhibited bythe ATP mimic Y27632, which competitively binds the ATP binding …
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REDOX-RESPONSIVE POLYMER DELIVERY SYSTEMS FOR ANTI-CANCER DRUG AND IMAGING
Cancer is one of the major human killers. Delivery systems for anti-cancer drugs and imaging agents play important roles in cancer treatment and diagnosis. For development of safe and efficient delivery systems, stimuli-responsive polymers which undergo significant physical or chemical properties …
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Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs.
… activity towards the inhibition of prostate cancer cell growth using staurosporine a a positive control. All three compounds have shown significant inhibition of prostate cancer cell growth. Compound <b>9</b> is yet to be evaluated.</p>
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Synthesis of Ester Derivatives of Resveratrol as Potential Anti-Cancer Drugs
… red wine. Resveratrol has been found to exhibit anti-cancer, anti-inflammatory, anti-aging, and anti-oxidant properties. Research indicates that diets enriched with resveratrol containing substances result in less incidence of cancer. Unfortunately, the low bioavailability and solubility has been …
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Engineering of polyphenol metabolism in tomatoes to enhance anti-cancer activities
… chronic, non-communicable diseases such as cancer, type 2 diabetes and cardiovascular diseases. High-anthocyanin tomato extracts induced cell death, cell cycle alteration and apoptosis in the human breast cancer cell lines, MCF-7 and MDA-MB-231, whilst WT tomato extracts exerted no …
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