Búsqueda de mutaciones en el gen foxo4 en pacientes con falla ovárica prematura no-sindrómica

FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups.

Grantor dc:publisher

Universidad del Rosario

Year dc:date

2015

Author dc:creator

• Garzón Venegas, Eliana del Pilar

• Female infertility
• FOXO4
• Premature ovarian failure
• Ginecología & otras especialidades médicas
• Infertilidad Femenina
• Insuficiencia ovárica primaria
• Genética

Statement dc:rights

• info:eu-repo/semantics/openAccess

Licence

• http://creativecommons.org/licenses/by-nc-nd/2.5/co/

Language dc:language

spa

Identifier

http://repository.urosario.edu.co/handle/10336/11513

OAI identifier oai:identifier

oai:repository.urosario.edu.co:10336/11513