Búsqueda de mutaciones en el gen foxo4 en pacientes con falla ovárica prematura no-sindrómica
type: CreativeWork
description: FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups.
abstract: FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups.
author: Garzón Venegas, Eliana del Pilar
language: spa
keywords: Female infertility, FOXO4, Premature ovarian failure, Ginecología & otras especialidades médicas, Infertilidad Femenina, Insuficiencia ovárica primaria, Genética
license: http://creativecommons.org/licenses/by-nc-nd/2.5/co/
date published: 2015-07-31
date modified: 2026-07-27T20:46:36Z
provider: Universidad del Rosario
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Universidad del Rosario

PropertyValue
property ID: DOI
value: 10.48713/10336_11513