Pharmacological and Genetic Effects of Serotonin on Value-Based Decision-Making

This doctoral thesis investigated the role of the neuromodulator serotonin on four different value-based decision making tasks, using an acute tryptopahin intervention and an associative genetic approach - a naturally occuring variation in the promoter region of the serotonin transporter gene (5-HTTLPR). Additionally, structural (DTI) and functional aspects (BOLD-fMRI) of the brain were assessed using magnetic resonance imaging in relation to decision-making. Overall, we only found limited evidence for a serotonergic effect on decision-making that was restricted to a genetic association with risk-seeking for losses behaviour that could no be corroborated by differences in tonic serotonin levels or white matter microstructure.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Technische Universität Dresden

Year

2020

Author dc:creator

• Neukam, Philipp T.

Contributors dc:contributor

• Smolka, Michael N.
• Strobel, Alexander

• Serotonin
• Tryptophan
• 5-HTTLPR
• Entscheidungsverhalten
• fMRT
• DTI
• decision making
• fMRI