Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"5-HTTLPR"”.
-
5-HTTLPR, DRD4 gene, college students’ psychological characters and academic performance
… is to evaluate associations between the 5-HTTLPR, the DRD4 gene, psychological characteristics including metacognition and depression, and academic performance as reflected in SAT scores. We discovered that participants with 2-repeat or 7-repeat alleles of the DRD4 gene have significantly …
-
Impact of the Serotonin-Transporter-Polymorphism (5-HTTLPR) and Stressful Life Events on the Stress Response in Humans
… a common polymorphism in the promoter region (5-HTTLPR), which has functional consequences. Two major alleles have been observed and shown to have differential transcriptional activity with the long (L) allele having greater gene expression than the short (S) allele. 5-HTTLPR appears to modulate …
-
The biological bases of social deficits: the roles of social motivation, theory of mind, and selected genotypes (OPRM1, 5-HTTLPR) in autism spectrum disorder
… transporter promoter length polymorphism (5-HTTLPR) respectively. For the first study of this protocol, I assessed the possible relationships between social motivation, OPRM1, and the ASD phenotype. For the second study, I assessed possible relationships between ToM deficits, 5-HTTLPR, and …
-
An exploration of the relationship between autism spectrum disorders, theory of mind and the serotonin transporter promoter length polymorphism
… transporter promoter length polymorphism (5 - HTTLPR) has been implicated in ASD, and as serotonin is implicated in social functioning more generally, it is possible that 5 - HTTLPR could underlie social functioning in ASD. As such, ToM and 5 - HTTLPR have been implicated in ASD, and …
-
Imputation of Microsatellite Markers With Tag SNPs
… in particular on imputing a VNTR polymorphism, 5-HTTLPR, in the promoter region of the serotonin transporter gene in a small sample of individuals from an ongoing neuroimaging genetics study, a portion of whom have both manual 5-HTTLPR genotypes and genome wide SNP data. We investigate four …
-
The serotonin transporter gene (SLC6A4) shows differential regulation between children with ASD and typically developing children in a South African population
… focuses on a length polymorphic repeat region (5-HTTLPR) upstream of the SLC6A4 promoter, and SLC6A4 promoter DNA methylation. The short variant of 5-HTTLPR is directly linked to lowered SLC6A4 expression and is at higher frequencies in ASD populations. DNA methylation at the promoter of SLC6A4 is …
-
The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing
… of the serotonin transporter (5-HTT) gene (5-HTTLPR): Carriers of the short (S) allele which results in a reduced gene ex-pression showed a stronger startle magnitude which is in line with numerous findings linking the S allele to increased measures of negative emotionality. In addition to …
-
Pharmacological and Genetic Effects of Serotonin on Value-Based Decision-Making
… region of the serotonin transporter gene (5-HTTLPR). Additionally, structural (DTI) and functional aspects (BOLD-fMRI) of the brain were assessed using magnetic resonance imaging in relation to decision-making. Overall, we only found limited evidence for a serotonergic effect on …
-
Gene discovery: Polymorphism association with obsessive-compulsive disorder and proteome analysis of Artemisia annua.
… 5-HT1Dβ G861C polymorphism and the 5-HTTLPR 44-bp deletioninsertion. There was a higher frequency of the DRD2 A2 allele (p = 0.020) and a higher frequency of the low-activity COMT allele (p = 0.035) in male OCD patients compared to male controls. In addition, we observed an …
-
The effect of genotype on attention bias in rhesus macaques, Macaca mulatta, as a welfare indicator.
… in the following genes: serotonin transporter (5-HTTLPR; short and long allele), tryptophan hydroxylase 2 (TPH2; short and long allele), monoamine oxidase A (MAOA; 5-, 6- and 7-repeat allele) and mu-opioid receptor (OPRM1; C and G allele). Additionally, sequencing was utilised to identify novel …
-
The Social Environment, Genetics, and Obesity: Evaluation of Diathesis-Stress and Differential Susceptibility Frameworks
… the current study explores how the MAOA and 5-HTTLPR gene alleles interact with known predictors of obesity to compare and contrast the different frameworks. Results reveal that MAOA and 5-HTT do not have the same effect on obesity, especially when socioeconomic status and gender are …
-
Interaction Effects between the Cumulative Genetic Score and Psychosocial Stressor on Drinking Urge and Attentional Bias for Alcohol: A Human Laboratory Study
… a function of the cumulative genetic index of 5-HTTLPR, MAO-A, DRD4, DAT1, and DRD2 genotypes (candidate genes and environment interaction; cGxE). The current study also examined whether salivary alpha-amylase level or anxiety state mediate the cGxE effects. One hundred five Caucasian young …
-
Psychological and Genetic Contributions to the Development of Social Cognition in Children
… least one risk allele in both the DRD4 and the 5-HTTLPR polymorphisms would perform worse than those who had at least one risk allele in either polymorphism, who, in turn, would perform worse than children without any risk alleles. The twin sample included 62 families of multiples (twins, …
-
Cortisol in Middle Childhood: Associations with Genetic Polymorphisms and Early Environmental Risk
… polymorphisms (COMT Val158Met, MAOA-LPR, and 5-HTTLPR) has yielded well publicized but inconsistently replicated associations with mental health. Part of this inconsistency may be due to the limited exploration of mechanistic explanations for how these gene-environment interactions lead to …
-
Neurochemische und autoradiographische Untersuchungen von Serotonin-Transporter-Knockout-Mäusen
… somit den Verdacht, dass das kurze Allel des 5-HTTLPR, welches mit einer geringeren Expression von 5-HTT einhergeht, einen Risikofaktor für die Entstehung von late-onset Alzheimer-Demenzen (mit spätem Beginn) darstellt. Bei 5-HTT-Knockout Mäusen besteht eine signifikante Hoch-Regulation der …
-
Molekulargenetische Aspekte dopaminerger Modulation der Responsivität gegenüber Neuheit
… die Dopamin-Funktion beeinflussen (COMT, 5-HTTLPR). In Studie II konnten die Ergebnisse einer vorhergehenden Arbeit repliziert werden, die einen Effekt des DRD4 Exon III 7-Repeat-Allels nur für bestimmte Genotyp-Gruppierungen der anderen beiden Polymorphismen zeigte. Zudem kann anhand der …
-
Investigating disturbances of brain 5-HT systems by experimental MRI and SPECT neuroimaging
… 5-HTT gene-linked polymorphic region (5-HTTLPR) of the SERT gene has been shown to predispose to depression, the SERT assumes a key role in depression. Traditionally, depression severity was assessed using psychological testing of patients. However in the last 20 years, neuroimaging …
-
Stress and Suicidal Behavior: A Cognitive, Behavioral, and Biological Integrative Approach
<p>Suicide is one of the leading causes of death in young adults in the United States. Previous research has established distal and proximal life stress as a strong risk factor for suicidal behavior. However, how stress impacts suicidal behavior via interactive cognitive and biological mechanisms …