{"id":{"repo_id":"qucosa-diss","oai_identifier":"oai:qucosa:de:qucosa:72072"},"canonical_url":"https://search.dev.ndltd.org/etd/qucosa-diss/oai:qucosa:de:qucosa:72072","repository":{"repo_id":"qucosa-diss","name":"QUCOSA","base_url":"http://www.qucosa.de/oai/"},"display":{"title":"Pharmacological and Genetic Effects of Serotonin on Value-Based Decision-Making","abstract":"This doctoral thesis investigated the role of the neuromodulator serotonin on four different value-based decision making tasks, using an acute tryptopahin intervention and an associative genetic approach - a naturally occuring variation in the promoter region of the serotonin transporter gene (5-HTTLPR). Additionally, structural (DTI) and functional aspects (BOLD-fMRI) of the brain were assessed using magnetic resonance imaging in relation to decision-making. Overall, we only found limited evidence for a serotonergic effect on decision-making that was restricted to a genetic association with risk-seeking for losses behaviour that could no be corroborated by differences in tonic serotonin levels or white matter microstructure.","abstract_html":"This doctoral thesis investigated the role of the neuromodulator serotonin on four different value-based decision making tasks, using an acute tryptopahin intervention and an associative genetic approach - a naturally occuring variation in the promoter region of the serotonin transporter gene (5-HTTLPR). Additionally, structural (DTI) and functional aspects (BOLD-fMRI) of the brain were assessed using magnetic resonance imaging in relation to decision-making. Overall, we only found limited evidence for a serotonergic effect on decision-making that was restricted to a genetic association with risk-seeking for losses behaviour that could no be corroborated by differences in tonic serotonin levels or white matter microstructure.","abstract_has_math":false,"creators":["Neukam, Philipp T."],"institution":"Technische Universität Dresden","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Smolka, Michael N.","Strobel, Alexander"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-06-29","date_published":"2020-06-29","updated_at":"2026-07-24T03:56:21Z","subjects":["Serotonin","Tryptophan","5-HTTLPR","Entscheidungsverhalten","fMRT","DTI","decision making","fMRI"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Smolka, Michael N.","Strobel, Alexander"]},{"key":"dc:creator","label":"Author","values":["Neukam, Philipp T."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Technische Universität Dresden"]},{"key":"dc:type","label":"Dc Type","values":["doctoralThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Technische Universität Dresden"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Serotonin","Tryptophan","5-HTTLPR","Entscheidungsverhalten","fMRT","DTI","decision making","fMRI"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This doctoral thesis investigated the role of the neuromodulator serotonin on four different value-based decision making tasks, using an acute tryptopahin intervention and an associative genetic approach - a naturally occuring variation in the promoter region of the serotonin transporter gene (5-HTTLPR). Additionally, structural (DTI) and functional aspects (BOLD-fMRI) of the brain were assessed using magnetic resonance imaging in relation to decision-making. Overall, we only found limited evidence for a serotonergic effect on decision-making that was restricted to a genetic association with risk-seeking for losses behaviour that could no be corroborated by differences in tonic serotonin levels or white matter microstructure.","In der vorliegenden Doktorarbeit wurde die Rolle des Neuromodulators Serotonin hinsichtlich vier verschiedener wertbasierter Entscheidungsfindungsaufgaben untersucht, wobei eine akute Tryptophanintervention und ein assoziativer genetischer Ansatz, eine natürlich vorkommende Variation in der Promoterregion des Serotonintransportergens (5-HTTLPR), zur Anwendung gekommen sind. Zusätzlich wurden strukturelle (DTI) und funktionelle Aspekte (BOLD-fMRI) des Gehirns mittels Magnetresonanztomographie in Bezug auf die Entscheidungsfindung erhoben. Insgesamt fanden wir nur eine begrenzte Evidenz eines serotonergen Effekts auf Entscheidungsverhalten, die sich auf eine genetische Assoziation mit risikofreudigem Verhalten bei Verlusten beschränkte. Diese Assoziation ließ sich nicht durch Unterschiede im tonischen Serotoninspiegel oder der Mikrostruktur der weißen Substanz erhärten."]},{"key":"dc:title","label":"Title","values":["Pharmacological and Genetic Effects of Serotonin on Value-Based Decision-Making"]}]}],"canonical_facts":{"dc:contributor":["Smolka, Michael N.","Strobel, Alexander"],"dc:creator":["Neukam, Philipp T."],"dc:description.abstract":["This doctoral thesis investigated the role of the neuromodulator serotonin on four different value-based decision making tasks, using an acute tryptopahin intervention and an associative genetic approach - a naturally occuring variation in the promoter region of the serotonin transporter gene (5-HTTLPR). Additionally, structural (DTI) and functional aspects (BOLD-fMRI) of the brain were assessed using magnetic resonance imaging in relation to decision-making. Overall, we only found limited evidence for a serotonergic effect on decision-making that was restricted to a genetic association with risk-seeking for losses behaviour that could no be corroborated by differences in tonic serotonin levels or white matter microstructure.","In der vorliegenden Doktorarbeit wurde die Rolle des Neuromodulators Serotonin hinsichtlich vier verschiedener wertbasierter Entscheidungsfindungsaufgaben untersucht, wobei eine akute Tryptophanintervention und ein assoziativer genetischer Ansatz, eine natürlich vorkommende Variation in der Promoterregion des Serotonintransportergens (5-HTTLPR), zur Anwendung gekommen sind. Zusätzlich wurden strukturelle (DTI) und funktionelle Aspekte (BOLD-fMRI) des Gehirns mittels Magnetresonanztomographie in Bezug auf die Entscheidungsfindung erhoben. Insgesamt fanden wir nur eine begrenzte Evidenz eines serotonergen Effekts auf Entscheidungsverhalten, die sich auf eine genetische Assoziation mit risikofreudigem Verhalten bei Verlusten beschränkte. Diese Assoziation ließ sich nicht durch Unterschiede im tonischen Serotoninspiegel oder der Mikrostruktur der weißen Substanz erhärten."],"dc:publisher":["Technische Universität Dresden"],"dc:subject":["Serotonin","Tryptophan","5-HTTLPR","Entscheidungsverhalten","fMRT","DTI","decision making","fMRI"],"dc:title":["Pharmacological and Genetic Effects of Serotonin on Value-Based Decision-Making"],"dc:type":["doctoralThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Technische Universität Dresden"]},"updated_at":"2026-07-24T03:56:21Z"}