Shape-switching studies with cyclophanes and indicator displacement assays with boronic acids

This thesis includes the development of indicator displacement assays (IDAs) with a boronic acid receptor, used for the differentiation of Z and E alkene mixtures. An IDA protocol was developed which is ammenable to high-throughput screening and can successfully identify Z and E alkene mixtures with an average absolute error of eight percent. The second research chapter includes the synthesis and analysis of shape-switching cyclophane hosts with a range of molecular guests. This research serves as a contribution towards the field of molecular machines and switches which may gain utility in the fields of drug delivery or catalysis.<br/>

Name dc:type.qualificationname

Doctor of Philosophy

Level dc:type.qualificationlevel

Doctoral Thesis

Grantor dc:publisher.institution

Queen's University Belfast

Year dc:date.issued

2021

Author dc:creator

• Crory, Hannah

Advisor dc:contributor.advisor

• De Silva, Amilra

• Supramolecular chemistry
• fluorescence

Language dc:language

eng

Identifier

oai:pure.qub.ac.uk/portal:studenttheses/07434dbf-2311-4935-9b3d-8b4f7f074d55

OAI identifier oai:identifier

oai:pure.qub.ac.uk/portal:studenttheses/07434dbf-2311-4935-9b3d-8b4f7f074d55