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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"Boronic acid"”.
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Tetracycline-7-boronic acid
The objective of this study is the preparation of a tetracycline-boron-10 derivative which is stable under biological conditions. The boron-10 should then provide a concentration of material capable of accepting thermal neutrons, thus producing localized high-energy alpha radiation. The fact that …
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Synthesis and Application of Boronic Acid Derivatives
Boronic acids are attractive synthetic intermediates and have been shown to be effective as inhibitors of various enzymes. In this project, the overarching goal is the selective inhibition of a protease present in the mitochondria known as human ClpXP. To study the potential selective inhibition of …
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Photoredox C–C Cross-Coupling Reactions using Boronic Acid Derivatives
… as reagents in organic synthesis, the use of boronic acid derivatives to generate carbon-centred radicals remains elusive. This dissertation explores the utilisation of photoredox catalysis to generate carbon radicals from boronic acid derivatives and subsequently engage them in C–C …
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A kinetic investigation of boronic acid/diol interactions and pattern-based recognition of [alpha]-chiral carboxylates
Amine-functionalized boronic acids have revolutionized the field of carbohydrate sensing in recent years. Capable of rapidly and reversibly forming cyclic boronate esters with of 1,2- and 1,3-diols, polyols, catechols, and α-hydroxycarboxylic acids, boronic acids have found applications spanning …
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Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids
… via redox pathways have provided nucleic acid researchers access to the efficiency and quantitative nature of the click reaction. The majority of ligation procedures in the literature are performed in solution after DNA assembly and modification with alkyne reporter groups. However, …
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Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation
… screening of a 3.3.4 branched peptide boronic acids (BPBAs) library that bind selectively to the tertiary structure of RRE IIB. The library comprised of 46,656 unique sequences. We demonstrate that our highest affinity BPBA (BPBA1) selectively binds RRE IIB in the presence of competitor …
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Thiol-Norbornene Hydrogels With Tunable Mechanical Properties for Engineered Extracellular Matrices
… was designed to yield dynamically adaptable boronic ester bonds via partial enzymatic reaction. Thiol-norborne hydrogel was made to contain hydroxyl phenol as well as boronic acid residues within its network. MT, in this case was used to oxidize the hydroxy phenol moieties into DOPA, which …
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Examination of UV-Cross-Linkable Di-Block Copolymer Strategy for Functionalized Reaction Surface on Microelectrode Arrays
… coating for the array. Finally, a copolymer with boronic acid functionality, PCEMA-b-BoSt was made in order to test the versatility of the boronic acid as a starting material for building other functionalities. The boronic acid derived polymer performs better than the previous coating in terms of …
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Transmetalation from boronic esters to arylpalladium complexes without prior hydrolysis – mechanistic studies and preparative applications in the anhydrous, Suzuki-Miyaura cross-coupling reaction
… pre-transmetalation intermediates incorporating boronic esters have been characterized, proving the competency of boronic esters to undergo transmetalation without prior hydrolysis. Boronic ester structure was found to have a significant impact on both pretransmetalation intermediate speciation …
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Shape-switching studies with cyclophanes and indicator displacement assays with boronic acids
… of indicator displacement assays (IDAs) with a boronic acid receptor, used for the differentiation of Z and E alkene mixtures. An IDA protocol was developed which is ammenable to high-throughput screening and can successfully identify Z and E alkene mixtures with an average absolute error of …
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Synthetic routes to hydroxyaucanebobonic acids and their derivatives
… of synthetic routes leading to hydroxyalkaneboronic acids, which were expected to display some useful and interesting biological and chemical properties, has been carried out with reference to reaction sequences involving the hydroboration of alkenes and interaction of Grignard reagents with …
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Pre-transmetalation intermediates in the Suzuki-Miyaura reaction revealed: the missing link
… and the wide variety of commercially available boronic acid substrates. Despite the popularity of the Suzuki-Miyaura reaction, the precise manner in which the organic fragment is transferred from boron to palladium has remained elusive for over 30 years. The work described in this dissertation …
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Saccharide recognition : boronic acids as receptors in polymeric networks
In this thesis entitled “Saccharide Recognition - Boronic acids as Receptors in Polymeric Networks” different aspects of boronic acid synthesis, their analysis and incorporation or attachment to different polymeric networks and characterisation thereof were investigated. The following key aspects …
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Catalytic and Biological Applications of Benzoxaborolones
Though first isolated 150 years ago, boronic acids have historically been neglected species. The more recent advent of transition metal-catalyzed reactions has led to an explosion in their use as building blocks, which in turn has led to their application in many other contexts as synthetic methods …
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A synthesis of a homologous series of aryl mono- and diboronic acids
<p>Many attempts have been made to prepare aryl boronic acids and their esters which show a preferential affinity for tumor tissues for use in radiation therapy of neoplatic disorders (1,2). The data of Soloway, as extended and refined by Hansch and his coworkers, successfully correlates the low …
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Developing test strips for naked-eye detection of alpha-hydroxy acids using indicator-displacement assays: an application of molecular recognition
… Two examples are the dihydroxylation of maleic acid and fumaric acid catalyzed by osmium tetroxide in water, and the hydrolysis of D-dimethyl tartrate. The assay employed a receptor that has 1,3,5-trisubstituted-2,4,6- triethylbenzene scaffold incorporating boronic acid and guanidinium moieties …
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Luminescent Iridium(III) Cyclometalated Complexes: Host-Guest Chemistry and Application as Sensors
… displayed the highest solubility in oleic acid (as an example of fatty acid that present in fingerprints). A boronic acid group (B(OH)2) was introduced to the bpy ligand to form B(OH)2-Ir-H, which was used as a sensor for peroxide detection, based on the ability of hydrogen peroxide (H2O2) …
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Part I: synthesis and cross-coupling of the C1-C12 primary organoborane building block of amphotericin B; Part II: site- and stereoretentive cross-coupling of unactivated secondary boronic acids inspired by amphotericin B
… idealized limit, a collection of off-the-shelf boronic acid-based building blocks having all of the required functional groups pre-installed in the correct oxidation states and with the desired stereochemical relationships are readily assembled using only a single cross-coupling reaction …
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