STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH

The exploitation of the copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has contributed to drug discovery due to the high degree of dependability, efficiency, specificity and biocompatibility of the reactions and products. Using this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester to 4-azido-2,6-difluorophenol acetate. Characterizations of these materials were done using 1HNMR, 13CNMR, liquid chromatography mass spectrometry, and infrared spectroscopy.

Name thesis:degree_name

MS

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Arts and Sciences: Chemistry

Grantor dc:publisher

University of Cincinnati

Year dc:date

2012

Author dc:creator

• Tesak, Jennifer Lynn

Contributors dc:contributor

• Taylor, Richard
• Hartley, Scott

• Chemistry
• click chemistry
• apoptosis inhibitor Q-VD-OPh
• NSAID

Statement dc:rights

• unrestricted
• This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

Language dc:language

English

Repository record dc:identifier

http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335402166

OAI identifier oai:identifier

oai:etd.ohiolink.edu:ucin1335402166