{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:ucin1335402166"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:ucin1335402166","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH","abstract":"The exploitation of the copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has contributed to drug discovery due to the high degree of dependability, efficiency, specificity and biocompatibility of the reactions and products. Using this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester to 4-azido-2,6-difluorophenol acetate. Characterizations of these materials were done using 1HNMR, 13CNMR, liquid chromatography mass spectrometry, and infrared spectroscopy.","abstract_html":"The exploitation of the copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has contributed to drug discovery due to the high degree of dependability, efficiency, specificity and biocompatibility of the reactions and products. Using this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester to 4-azido-2,6-difluorophenol acetate. Characterizations of these materials were done using 1HNMR, 13CNMR, liquid chromatography mass spectrometry, and infrared spectroscopy.","abstract_has_math":false,"creators":["Tesak, Jennifer Lynn"],"institution":"University of Cincinnati","degree_name":"MS","degree_level":"masters","degree_discipline":"Arts and Sciences: Chemistry","degree_department":null,"school":null,"contributors":["Taylor, Richard","Hartley, Scott"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-24T03:36:23Z","subjects":["Chemistry","click chemistry","apoptosis inhibitor Q-VD-OPh","NSAID"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335402166","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Taylor, Richard","Hartley, Scott"]},{"key":"dc:creator","label":"Author","values":["Tesak, Jennifer Lynn"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2012"]},{"key":"dc:publisher","label":"Institution","values":["University of Cincinnati / OhioLINK"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Arts and Sciences: Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["MS"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Cincinnati"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry","click chemistry","apoptosis inhibitor Q-VD-OPh","NSAID"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. 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Characterizations of these materials were done using 1HNMR, 13CNMR, liquid chromatography mass spectrometry, and infrared spectroscopy."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","p.44","1016.6 KB"]},{"key":"dc:title","label":"Title","values":["STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH"]}]}],"canonical_facts":{"dc:contributor":["Taylor, Richard","Hartley, Scott"],"dc:creator":["Tesak, Jennifer Lynn"],"dc:date":["2012"],"dc:description":["The exploitation of the copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has contributed to drug discovery due to the high degree of dependability, efficiency, specificity and biocompatibility of the reactions and products. Using this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester to 4-azido-2,6-difluorophenol acetate. Characterizations of these materials were done using 1HNMR, 13CNMR, liquid chromatography mass spectrometry, and infrared spectroscopy."],"dc:format":["application/pdf","p.44","1016.6 KB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335402166"],"dc:language":["English"],"dc:publisher":["University of Cincinnati / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"dc:subject":["Chemistry","click chemistry","apoptosis inhibitor Q-VD-OPh","NSAID"],"dc:title":["STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Arts and Sciences: Chemistry"],"thesis:degree_level":["masters"],"thesis:degree_name":["MS"],"thesis:institution_name":["University of Cincinnati"]},"updated_at":"2026-07-24T03:36:23Z"}