MULTIFUNCTIONAL SUPRAMOLECULAR DELIVERY SYSTEM FOR ENHANCING TUMOR IMMUNOTHERAPY

Immunotherapy, which activates the immune system to recognize and destroy cancer cells, holds promise for long-term tumor defense. This Ph.D. thesis explores enhancing tumor immunotherapy efficiency through β-cyclodextrin (β-CD)-based delivery systems. By utilizing host-guest supramolecular chemistry, β-CD carriers were combined with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the formed nanoparticles allowed conjugation of proteins such as antibodies against programmed death-ligand 1 (aPD-L1, atezolizumab). These engineered carriers address challenges in drug solubility, targeting, and immunotherapy. The findings highlight the potential of β-CD-based systems to revolutionize cancer immunotherapy, providing valuable insights for future research.

Author dc:creator

• TANG XICHUAN

• fluorescence
• immunotherapies
• photothermal therapies
• supramolecular chemistry
• cyclodextrins