{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/249568"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/249568","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"MULTIFUNCTIONAL SUPRAMOLECULAR DELIVERY SYSTEM FOR ENHANCING TUMOR IMMUNOTHERAPY","abstract":"Immunotherapy, which activates the immune system to recognize and destroy cancer cells, holds promise for long-term tumor defense. This Ph.D. thesis explores enhancing tumor immunotherapy efficiency through β-cyclodextrin (β-CD)-based delivery systems. By utilizing host-guest supramolecular chemistry, β-CD carriers were combined with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the formed nanoparticles allowed conjugation of proteins such as antibodies against programmed death-ligand 1 (aPD-L1, atezolizumab). These engineered carriers address challenges in drug solubility, targeting, and immunotherapy. The findings highlight the potential of β-CD-based systems to revolutionize cancer immunotherapy, providing valuable insights for future research.","abstract_html":"Immunotherapy, which activates the immune system to recognize and destroy cancer cells, holds promise for long-term tumor defense. This Ph.D. thesis explores enhancing tumor immunotherapy efficiency through β-cyclodextrin (β-CD)-based delivery systems. By utilizing host-guest supramolecular chemistry, β-CD carriers were combined with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the formed nanoparticles allowed conjugation of proteins such as antibodies against programmed death-ligand 1 (aPD-L1, atezolizumab). These engineered carriers address challenges in drug solubility, targeting, and immunotherapy. The findings highlight the potential of β-CD-based systems to revolutionize cancer immunotherapy, providing valuable insights for future research.","abstract_has_math":false,"creators":["TANG XICHUAN"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-08-23","date_published":"2023-08-23","updated_at":"2026-07-24T03:33:09Z","subjects":["fluorescence","immunotherapies","photothermal therapies","supramolecular chemistry","cyclodextrins"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["TANG XICHUAN"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2023-08-23"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/249568"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["fluorescence","immunotherapies","photothermal therapies","supramolecular chemistry","cyclodextrins"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/ed697439-9fa7-49df-b928-aaba74165aaa/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Immunotherapy, which activates the immune system to recognize and destroy cancer cells, holds promise for long-term tumor defense. This Ph.D. thesis explores enhancing tumor immunotherapy efficiency through β-cyclodextrin (β-CD)-based delivery systems. By utilizing host-guest supramolecular chemistry, β-CD carriers were combined with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the formed nanoparticles allowed conjugation of proteins such as antibodies against programmed death-ligand 1 (aPD-L1, atezolizumab). These engineered carriers address challenges in drug solubility, targeting, and immunotherapy. 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By utilizing host-guest supramolecular chemistry, β-CD carriers were combined with hydrophobic molecules lonidamine (LND) and indocyanine green (ICG). in additional, after functional modification, the formed nanoparticles allowed conjugation of proteins such as antibodies against programmed death-ligand 1 (aPD-L1, atezolizumab). These engineered carriers address challenges in drug solubility, targeting, and immunotherapy. 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