Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system

Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this work, a modified Apparatus 2, termed "OPI" System for "off-center paddle impeller," in which the impeller is placed 8 mm off center in the vessel is tested to determine its sensitivity to differentiate between the dissolution profiles of differently formulated and manufactured tablets. Dissolution tests are conducted with both the OPI System and the Standard System using three different brands of aspirin at nine different tablet positions. The OPI system produces dissolution profiles that are highly dependent on the different brands of aspirin used, similarly to those generates in the Standard System. However, the dissolution profiles obtained with the OPI apparatus are found to be largely independent of the tablet location at the vessel bottom, whereas those obtained in the Standard System generates statistically different profiles depending on tablet location. It can be concluded that the newly proposed OPI system can effectively eliminate artifacts generated by random settling of the tablet at the vessel bottom, thus making the test more robust, while at the same time being just as sensitive as the Standard System to actual differences in differently manufactured tablets having intrinsically different dissolution profiles.

Name thesis:degree_name

Master of Science in Pharmaceutical Engineering - (M.S.)

Discipline thesis:degree_discipline

Chemical, Biological and Pharmaceutical Engineering

Year

2013

Author dc:creator

• Qu, Yang

Contributors dc:contributor

• Piero M. Armenante
• Laurent Simon
• Gerard Bredael

• Dissolution testing
• Off-center paddle impeller
• Modified dissolution testing apparatus 2
• Chemical Engineering
• Pharmaceutics and Drug Design

Repository record dc:identifier

https://digitalcommons.njit.edu/theses/161

OAI identifier oai:identifier

oai:digitalcommons.njit.edu:theses-1160