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Showing 1 to 20 of 28 for “"Dissolution profiles"”.
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Effect of tablet compression on the dissolution of aspirin tablets using a novel off-center paddle impeller (opi) dissolution testing system
In the pharmaceutical industry, dissolution testing is routinely carried out to determine the dissolution rate of oral solid dosage forms. Among several testing devices, the USP Dissolution Apparatus 2 is the device most commonly used. However, despite its widespread use, this apparatus has been …
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Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system
Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this …
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Hydrodynamic effects of a cannula in a USP dissolution testing apparatus 2
Dissolution testing is routinely used in the pharmaceutical industry to provide in vitro drug release information for drug development and quality control purposes. The USP Testing Apparatus 2 is the most common dissolution testing system for solid dosage forms. Usually, sampling cannulas are used …
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Dissolution of disintegrating solid dosage forms in a modified dissolution testing apparatus 2
Dissolution tests are routinely carried out in the pharmaceutical industry to determine the dissolution rate of solid dosage forms. Dissolution testing serves as a surrogate for drug bioavailability through in vitro-in vivo correlation (IVIVR), and it additionally helps in guiding the development …
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Dissolution testing of prednisone and salicylic acid calibrator tablets at different tablet locations
Dissolution testing is routinely carried out in the pharmaceutical industry to determine the rate of dissolution of solid dosage forms. This test is one of the several tests that pharmaceutical companies typically conduct on oral dosage formulations (e.g., tablets) to determine compliance. The USP …
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Hydrodynamic effects of an arch-shaped fiber optic probe in a dissolution testing apparatus 2
Dissolution testing is widely used in the pharmaceutical industry to evaluate newly developed drug formulations and as a quality control method to insure that solid dosage forms have consistent dissolution property. Typically, samples are manually drawn from the dissolution vessel prior to …
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Novel Carbopol-Wax Blends for Controlled Release Oral Dosage Forms
… infrared spectrophotometer was used to predict dissolution profiles of propranolol sustained release tablets non-destructively. Three different modeling algorithms were compared for their predictability. K-nearest neighbors algorithm (KNN) yielded models with better predictability compared to …
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Hydrodynamics, dissolution, and mass transfer effects in different dissolution testing apparatuses and laboratory systems
Dissolution testing apparatuses and shaker flasks agitated by shaker tables are laboratory systems routinely found in many laboratories at most companies and agencies, and especially in pharmaceutical companies. These devices are commonly used in a number of applications, from drug development to …
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Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion–spheronization
… to that of the formulation containing MCC alone. Dissolution data of the optimised formulations were analysed in terms of mean dissolution time (MDT) as well as fit factors (f₁ and f₂). The optimised bead formulations had dissolution profiles comparable to that of the formulation containing MCC …
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Probabilistic models for drug dissolution
… and Inverse Monte-Carlo-based models for drug dissolution. Drug dissolution from different carriers is a complex phenomenon. Limited knowledge is available on some of the underlying constituent processes, which restricts development of mechanistic models. Monte Carlo techniques permit the …
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Comparative analysis of the dissolution performance of aspirin tablets in the usp apparatus 2 and in a minivessel dissolution system
Dissolution testing is a critical component of quality control procedures in the pharmaceutical industry in order to ensure that the final solid dosage forms have consistent dissolution properties. Dissolution tests are also routinely conducted to evaluate the in-vitro performance of solid dosage …
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… nevirapine (co-crystals). The solubility and dissolution profiles of the three compounds and those of selected ‘supramolecularly-derived’ species were also assessed. Three distinct phases of 2-methoxyestradiol (2ME) were successfully isolated, the most stable form (a polymorph) by the …
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Pharmaceutical tablet compaction : product and process design
… hardness and led to bursting behavior during dissolution. No effect of compaction force or speed was observed in dissolution profiles. Lactose granules fracture at strains less than 5%, forming monolithic structures with no evidence of initial granule shape or size. Pore size decreases as …
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Effects of operating and geometric variables on hydrodynamics and tablet dissolution in standard and modified dissolution testing apparatuses 2
Dissolution testing is routinely conducted in the pharmaceutical industry to provide critical in vitro drug release information for quality control purposes, and especially to assess batch-to-batch consistency of solid oral dosage forms such as tablets. Among the different types of apparatuses …
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QUANTIFICATION OF ASPARTAME IN LOZENGES AND TABLETOP SWEETENERS VIA MULTIPLE PARAMETER MANIPULATION BY USING DISSOLUTION STUDIES WITH UV-VIS, ULTRA-HPLC, AND MATHEMATICAL DRUG MODELING
… such as menthol, when studying the kinetics of dissolution.</p> <p>In this study, aspartame was analyzed in Halls and Ricola lozenges and other tabletop sweeteners such as NJoy, Natra, Equal powder and tablets. The dissolution test is one of the essential assays required to be passed before a …
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Development of Sodium Benzoate Tablets with Dual Burst Release: Hydrophilic Matrix System
… system over an eight-hour period. The targeted dissolution profile was defined as 25% release at 30–60 minutes, 50% ± 5% at five hours, 70% ± 5% at six hours, and 90–100% at eight hours. Dual burst release system is a method for regulating active pharmaceutical ingredient (API) release in two …
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Investigation of Amorphous Solid Dispersions of Poorly Water-soluble Drugs in Poly (2-hydroxyethyl Methacrylate) Hydrogels for Enhanced Solubility and Controlled Release
… in crosslinked PHEMA hydrogels to enhance the dissolution behavior of poorly water-soluble drugs. The first part of the study identifies physicochemical properties affecting the solid state and physical stability of ASD of the model drug indomethacin (IND) in PHEMA hydrogels. The results of the …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… Polymer precipitation inhibition efficiency and dissolution studies were conducted at 0.1 mg/mL and 0.05 mg/mL (70:30 w/w).|Glyceryl monoleate (GMO), Precirol® (glyceryl distearate, PRE), glyceryl monostearate (GMS) and COM® (glyceryl dibehenate, COM) were prepared with Gelucire (GEL) 44/14 or …
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Investigating Controlled Release Pulmonary Drug Delivery Systems
… particularly in areas of aerosol performance and dissolution profile. A hybrid protein-polymer controlled release pulmonary drug delivery system was developed to sustain the release of a water-soluble anti-asthma drug, cromolyn sodium (CS). Two excipients with complementary characteristics – a …
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Application of raman spectroscopy in pharmaceuticals
… from x-ray diffraction, SEM images and intrinsic dissolution profiles. An important result was the stabilization and characterization of the metastable type II orthorhombic phase of APAP which is highly desired for its unique tabletting properties which are important for pharmaceutical …
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