{"id":{"repo_id":"njit","oai_identifier":"oai:digitalcommons.njit.edu:theses-1160"},"canonical_url":"https://search.dev.ndltd.org/etd/njit/oai:digitalcommons.njit.edu:theses-1160","repository":{"repo_id":"njit","name":"NJIT","base_url":"https://digitalcommons.njit.edu/do/oai/"},"display":{"title":"Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system","abstract":"Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this work, a modified Apparatus 2, termed \"OPI\" System for \"off-center paddle impeller,\" in which the impeller is placed 8 mm off center in the vessel is tested to determine its sensitivity to differentiate between the dissolution profiles of differently formulated and manufactured tablets. Dissolution tests are conducted with both the OPI System and the Standard System using three different brands of aspirin at nine different tablet positions. The OPI system produces dissolution profiles that are highly dependent on the different brands of aspirin used, similarly to those generates in the Standard System. However, the dissolution profiles obtained with the OPI apparatus are found to be largely independent of the tablet location at the vessel bottom, whereas those obtained in the Standard System generates statistically different profiles depending on tablet location. It can be concluded that the newly proposed OPI system can effectively eliminate artifacts generated by random settling of the tablet at the vessel bottom, thus making the test more robust, while at the same time being just as sensitive as the Standard System to actual differences in differently manufactured tablets having intrinsically different dissolution profiles.","abstract_html":"Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this work, a modified Apparatus 2, termed "OPI" System for "off-center paddle impeller," in which the impeller is placed 8 mm off center in the vessel is tested to determine its sensitivity to differentiate between the dissolution profiles of differently formulated and manufactured tablets. Dissolution tests are conducted with both the OPI System and the Standard System using three different brands of aspirin at nine different tablet positions. The OPI system produces dissolution profiles that are highly dependent on the different brands of aspirin used, similarly to those generates in the Standard System. However, the dissolution profiles obtained with the OPI apparatus are found to be largely independent of the tablet location at the vessel bottom, whereas those obtained in the Standard System generates statistically different profiles depending on tablet location. It can be concluded that the newly proposed OPI system can effectively eliminate artifacts generated by random settling of the tablet at the vessel bottom, thus making the test more robust, while at the same time being just as sensitive as the Standard System to actual differences in differently manufactured tablets having intrinsically different dissolution profiles.","abstract_has_math":false,"creators":["Qu, Yang"],"institution":null,"degree_name":"Master of Science in Pharmaceutical Engineering - (M.S.)","degree_level":null,"degree_discipline":"Chemical, Biological and Pharmaceutical Engineering","degree_department":null,"school":null,"contributors":["Piero M. Armenante","Laurent Simon","Gerard Bredael"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-05-31T07:00:00Z","date_published":"2013-05-31T07:00:00Z","updated_at":"2026-07-24T03:22:26Z","subjects":["Dissolution testing","Off-center paddle impeller","Modified dissolution testing apparatus 2","Chemical Engineering","Pharmaceutics and Drug Design"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.njit.edu/theses/161","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Piero M. Armenante","Laurent Simon","Gerard Bredael"]},{"key":"dc:creator","label":"Author","values":["Qu, Yang"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical, Biological and Pharmaceutical Engineering"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Pharmaceutical Engineering - (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Dissolution testing","Off-center paddle impeller","Modified dissolution testing apparatus 2","Chemical Engineering","Pharmaceutics and Drug Design"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.njit.edu/theses/161"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this work, a modified Apparatus 2, termed \"OPI\" System for \"off-center paddle impeller,\" in which the impeller is placed 8 mm off center in the vessel is tested to determine its sensitivity to differentiate between the dissolution profiles of differently formulated and manufactured tablets. Dissolution tests are conducted with both the OPI System and the Standard System using three different brands of aspirin at nine different tablet positions. The OPI system produces dissolution profiles that are highly dependent on the different brands of aspirin used, similarly to those generates in the Standard System. However, the dissolution profiles obtained with the OPI apparatus are found to be largely independent of the tablet location at the vessel bottom, whereas those obtained in the Standard System generates statistically different profiles depending on tablet location. It can be concluded that the newly proposed OPI system can effectively eliminate artifacts generated by random settling of the tablet at the vessel bottom, thus making the test more robust, while at the same time being just as sensitive as the Standard System to actual differences in differently manufactured tablets having intrinsically different dissolution profiles."]},{"key":"dc:title","label":"Title","values":["Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system"]}]}],"canonical_facts":{"dc:contributor":["Piero M. Armenante","Laurent Simon","Gerard Bredael"],"dc:creator":["Qu, Yang"],"dc:description.abstract":["Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2. In this work, a modified Apparatus 2, termed \"OPI\" System for \"off-center paddle impeller,\" in which the impeller is placed 8 mm off center in the vessel is tested to determine its sensitivity to differentiate between the dissolution profiles of differently formulated and manufactured tablets. Dissolution tests are conducted with both the OPI System and the Standard System using three different brands of aspirin at nine different tablet positions. The OPI system produces dissolution profiles that are highly dependent on the different brands of aspirin used, similarly to those generates in the Standard System. However, the dissolution profiles obtained with the OPI apparatus are found to be largely independent of the tablet location at the vessel bottom, whereas those obtained in the Standard System generates statistically different profiles depending on tablet location. It can be concluded that the newly proposed OPI system can effectively eliminate artifacts generated by random settling of the tablet at the vessel bottom, thus making the test more robust, while at the same time being just as sensitive as the Standard System to actual differences in differently manufactured tablets having intrinsically different dissolution profiles."],"dc:identifier":["https://digitalcommons.njit.edu/theses/161"],"dc:subject":["Dissolution testing","Off-center paddle impeller","Modified dissolution testing apparatus 2","Chemical Engineering","Pharmaceutics and Drug Design"],"dc:title":["Dissolution of different commercial aspirin tablets using a novel off-center paddle impeller (OPI) dissolution testing system"],"dc:type":["Thesis"],"thesis:degree_discipline":["Chemical, Biological and Pharmaceutical Engineering"],"thesis:degree_name":["Master of Science in Pharmaceutical Engineering - (M.S.)"]},"updated_at":"2026-07-24T03:22:26Z"}