Detecting cervical dysplasia with quantitative spectroscopic imaging

This thesis extends quantitative spectroscopy, a form of model-based reflectance and fluorescence spectroscopy, from a small area, contact-probe implementation to wide-area quantitative spectroscopic imaging (QSI) for complete coverage of at-risk tissue. QSI uses the scanning virtual probe concept that is critical for model-based spectroscopy and offers spatial resolution advantages over conventional wide-field illumination. We develop a QSI system capable of imaging cervical dysplasia in vivo. Using the QSI system, we conduct a clinical study to train and prospectively evaluate QSI's ability to distinguish high-grade squamous intraepithelial lesions (HSIL) from non-HSILs (less severe conditions) in cervical transformation zone. This is a clinically important distinction because HSIL requires treatment. The results show measuring the per-patient normalized reduced scattering coefficient alone accurately performs the distinction. This is in good agreement with our previous contact-probe study of HSIL. Due to improved accuracy, QSI used as an adjunct to colposcopy can potentially reduce the number of unnecessary biopsies over colposcopy alone. The results also suggest a simplified optical instrument can be used to detect HSIL and this may advance cervical dysplasia detection in developing countries, where cervical cancer mortality is highest.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2009

Author dc:creator

• Lau, Condon

Advisor dc:contributor.advisor

• Michael Feld.

• Mechanical Engineering.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/106718

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/106718