{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/106718"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/106718","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Detecting cervical dysplasia with quantitative spectroscopic imaging","abstract":"This thesis extends quantitative spectroscopy, a form of model-based reflectance and fluorescence spectroscopy, from a small area, contact-probe implementation to wide-area quantitative spectroscopic imaging (QSI) for complete coverage of at-risk tissue. QSI uses the scanning virtual probe concept that is critical for model-based spectroscopy and offers spatial resolution advantages over conventional wide-field illumination. We develop a QSI system capable of imaging cervical dysplasia in vivo. Using the QSI system, we conduct a clinical study to train and prospectively evaluate QSI's ability to distinguish high-grade squamous intraepithelial lesions (HSIL) from non-HSILs (less severe conditions) in cervical transformation zone. This is a clinically important distinction because HSIL requires treatment. The results show measuring the per-patient normalized reduced scattering coefficient alone accurately performs the distinction. This is in good agreement with our previous contact-probe study of HSIL. Due to improved accuracy, QSI used as an adjunct to colposcopy can potentially reduce the number of unnecessary biopsies over colposcopy alone. The results also suggest a simplified optical instrument can be used to detect HSIL and this may advance cervical dysplasia detection in developing countries, where cervical cancer mortality is highest.","abstract_html":"This thesis extends quantitative spectroscopy, a form of model-based reflectance and fluorescence spectroscopy, from a small area, contact-probe implementation to wide-area quantitative spectroscopic imaging (QSI) for complete coverage of at-risk tissue. QSI uses the scanning virtual probe concept that is critical for model-based spectroscopy and offers spatial resolution advantages over conventional wide-field illumination. We develop a QSI system capable of imaging cervical dysplasia in vivo. Using the QSI system, we conduct a clinical study to train and prospectively evaluate QSI's ability to distinguish high-grade squamous intraepithelial lesions (HSIL) from non-HSILs (less severe conditions) in cervical transformation zone. This is a clinically important distinction because HSIL requires treatment. The results show measuring the per-patient normalized reduced scattering coefficient alone accurately performs the distinction. This is in good agreement with our previous contact-probe study of HSIL. Due to improved accuracy, QSI used as an adjunct to colposcopy can potentially reduce the number of unnecessary biopsies over colposcopy alone. The results also suggest a simplified optical instrument can be used to detect HSIL and this may advance cervical dysplasia detection in developing countries, where cervical cancer mortality is highest.","abstract_has_math":false,"creators":["Lau, Condon"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. 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QSI uses the scanning virtual probe concept that is critical for model-based spectroscopy and offers spatial resolution advantages over conventional wide-field illumination. We develop a QSI system capable of imaging cervical dysplasia in vivo. Using the QSI system, we conduct a clinical study to train and prospectively evaluate QSI's ability to distinguish high-grade squamous intraepithelial lesions (HSIL) from non-HSILs (less severe conditions) in cervical transformation zone. This is a clinically important distinction because HSIL requires treatment. The results show measuring the per-patient normalized reduced scattering coefficient alone accurately performs the distinction. This is in good agreement with our previous contact-probe study of HSIL. Due to improved accuracy, QSI used as an adjunct to colposcopy can potentially reduce the number of unnecessary biopsies over colposcopy alone. The results also suggest a simplified optical instrument can be used to detect HSIL and this may advance cervical dysplasia detection in developing countries, where cervical cancer mortality is highest."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Ph.D."]},{"key":"dc:title","label":"Title","values":["Detecting cervical dysplasia with quantitative spectroscopic imaging"]}]}],"canonical_facts":{"dc:contributor.advisor":["Michael Feld."],"dc:contributor.department":["Massachusetts Institute of Technology. Department of Mechanical Engineering."],"dc:contributor.other":["Massachusetts Institute of Technology. Department of Mechanical Engineering."],"dc:creator":["Lau, Condon"],"dc:date.accessioned":["2017-01-30T19:15:18Z"],"dc:date.available":["2017-01-30T19:15:18Z"],"dc:date.issued":["2009"],"dc:description":["Thesis (Ph. 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The results show measuring the per-patient normalized reduced scattering coefficient alone accurately performs the distinction. This is in good agreement with our previous contact-probe study of HSIL. Due to improved accuracy, QSI used as an adjunct to colposcopy can potentially reduce the number of unnecessary biopsies over colposcopy alone. The results also suggest a simplified optical instrument can be used to detect HSIL and this may advance cervical dysplasia detection in developing countries, where cervical cancer mortality is highest."],"dc:description.degree":["Ph.D."],"dc:identifier.uri":["http://hdl.handle.net/1721.1/106718"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["MIT theses are protected by copyright. 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