Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Estrogen regulates skeletal muscle mass and function in female. Estrogen may influence skeletal muscle mass and function during development in males as estrogen receptors (ER) have been identified in both female and male skeletal muscle. Whether estrogen exerts its effects on skeletal muscle through estrogen receptor alpha (ER[alpha]) or beta (ER[beta]) or directly during development is unclear. The main purpose of this study was to determine ER knock-out effects on muscle mass and contractile function in muscle with different fiber types, in mature female and male mice that were either ER[alpha] knock out (ER-/-) or ER[beta]-/- with corresponding wild type (WT) groups as controls. Loss of ER[alpha] results in increased Gast and TA muscle in female mice whereas the muscle functions are not affected, and ER[alpha] also influences female Plan muscle function. In contrast, ER[beta] might not have effects on skeletal muscle in female mice. ER-/- and Ar-/- result in decreased Gast and TA muscle in male mice, suggesting that estrogen/ER[alpha] signaling might directly regulate male muscle growth, whereas the muscle function are not affected. In contrast, ER[beta] might not have any effects on skeletal muscle in male mice.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Veterinary biomedical sciences (MU)

Grantor dc:publisher

University of Missouri--Columbia

Year dc:date.issued

2007

Author dc:creator

• Ning, Jie

Advisor dc:contributor.advisor

• Brown, Marybeth

Statement dc:rights

• Access to files is limited to the campuses of the University of Missouri with SSO login.

Language dc:language.iso

eng, English

DOI

https://doi.org/10.32469/10355/6273

OAI identifier oai:identifier

oai:mospace.umsystem.edu:10355/6273