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Showing 1 to 20 of 414 for “"knock-out"”.

  1. Phänotyp-Analyse der CHIF knock-out Maus

    Goldschmidt, Imeke

    … Befunde beitragen: <br>• In der Niere wird der knock-out des CHIF Gens unter Standardbedingungen, nach Vorbehandlung mit Glukokortikoiden sowie unter Kaliumbelastung gut kompensiert. Unter Na+-Restriktion zeigt die CHIF KO-Maus allerdings eine Einschränkung der K+-Ausscheidung. <br>• Im Kolon …

    freiburg-diss Repository record

  2. Characterization of the ProSAP1/Shank2 knock-out mouse

    Kübler, AngelikaUniversität Ulm

    ulm-diss Repository record

  3. Artificial Intron Technology to Generate Conditional Knock-Out Mice

    Thomas-Gordon, Amber N, <p>0000-0002-1319-5789</p>2020

    … gene expression. Such gene manipulation brings about significant findings and revelations in comprehending more about embryonic development, cellular and physiological functions, and disease pathology. Current methods used to produce conditional knockouts have limitations on conditional allele …

    uthsc Repository record

  4. ELECTROPHYSIOLOGICAL INVESTIGATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY IN DEAF-1 KNOCK-OUT MICE

    Ghosh, Aniruddha2017

    … mice with a brain specific conditional neuronal knock outs (NKO) of deaf 1 gene exhibited memory deficit and anxiety-like behavior. These deaf 1 NKO mice represent a convenient model for the study of the effects of ID on both in vivo and in vitro memory tests. Earlier studies in these deaf 1 NKOs …

    siu-theses Repository record

  5. Charakterisierung der Selenoproteine Thioredoxinreduktase 1 und 2 anhand von Knock-out-Mausmodellen

    Jakupoglu, CemileLudwig-Maximilians-Universität

    … present the establishment of a conditional TR1-knockout mouse strain and the phenotypical characterization of TR1- and of TR2-knockout mice, that have been established before. Both knockouts, TR1 and TR2, showed to be embryonically lethal. TR1 deficient mouse embryos died at day 9.5, whereas TR2 …

    lmu-germany Repository record

  6. Characterisation of Vti1b and Vti1a proteins and generation of knock-out mice.

    Atlachkine, Vadim2012

    … und kleinen Mäusen. Die normal großen Vti1b-knockout Mäuse haben keine nachweisbaren Defekte im Transport zum Lysosom, aber die Hepatozyten der kleinen Vti1b knockout Mäusen zeigen eine Verlangsamung im Proteintransport von späten Endosomen zu Lysosomen, erkennbar z.B. durch verlangsamten …

    goettingen Repository record

  7. Early onset of age related hearing loss in LDHB knock out mouse

    SAIHALI2014

    … study of Age-related hearing loss in LDHB knockout mice. In response to deletion of LDHB gene in mouse caused early onset of age related hearing loss, as increase of high frequency threshold, hair cell death, which are the typical features of Age-related hearing loss. We investigate the …

    ajou Repository record

  8. Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice

    Ning, JieUniversity of Missouri--Columbia2007

    … main purpose of this study was to determine ER knock-out effects on muscle mass and contractile function in muscle with different fiber types, in mature female and male mice that were either ER[alpha] knock out (ER-/-) or ER[beta]-/- with corresponding wild type (WT) groups as controls. Loss of …

    missouri Repository record

  9. Etablierung und Analyse von 'knock-out' Mausmodellen der σ1 Untereinheiten des AP 1 Komplexes

    Baltes, Jennifer2012

    Der multimere Adaptorproteinkomplex AP-1 ist ein wichtiger Bestandteil Clathrin umhüllter Vesikel, die zwischen dem Trans-Golgi-Netzwerk (TGN) und dem endosomalen Kompartiment den Proteintransport aufrechterhalten. Er besteht aus 4 Untereinheiten, die beiden großen Untereinheiten β und γ, die …

    goettingen Repository record

  10. Measurement of the fifth structure function in quasi-elastic proton knock-out from carbon

    Mandeville, Joseph BernardUniversity of Illinois at Urbana-Champaign2011

    … spectrometer in coincidence with quasi-elastic knock-out protons, which were detected in the new Out Of Plane Spectrometer (OOPS). We measured polarization asymmetries and total cross sections at a momentum transfer of 1.8 $fm\sp{-1}$ and at two proton angles out of the electron scattering plane …

    uiuc Repository record

  11. Altered Decision Behavior of Dopamine Receptor Knock-out Mice in a Free Binary Choice Task

    곽, 신애2015

    … the difference between actual and predicted outcomes (reward prediction error). However, the extent and nature of dopamine roles in reward-based learning are still under debate. Specific roles of different dopamine receptor subtypes in this process are also unknown. To investigate roles of …

    ajou Repository record

  12. Odvození a charakterizace SP6A knock-out mutantů jako nástroj pro studium procesu tuberizace u kulturního bramboru

    Myslivcová, JitkaUniverzita Karlova, Přírodovědecká fakulta2024

    … práce bylo na základě charakterizace linií s knock-outovaným SP6A genem objasnit úlohu SP6A v procesu tuberizace u kulturního bramboru. Pro mutagenezi jsem použila metodu CRISPR/Cas9 se specificky navrženou gRNA tak, aby došlo k editaci všech SP6A alel této tetraploidní rostliny. Komponenty …

    charles-prague Repository record

  13. Effect of Neurotoxic Insults in Knock Out Cell Lines for the Study of Alzheimer's Disease

    ΚΟΥΚΟΒΙΝΗ ΤΑΤΙΑΝΗ, KOUKOVINI TATIANI2026

    … της PD. Ο χαρακτηρισμός αυτών των μοντέλων knockout έδειξε ότι η απώλεια των PS1 και aSyn οδήγησε σε αυξημένα επίπεδα πλήρους μήκους APP (p=0,0469 και p=0,0174 αντίστοιχα), γεγονός που υποδηλώνει είτε διαταραχές στην επεξεργασία της APP είτε αλλαγές στην κυτταρική της μεταφορά. Αξιοσημείωτα, …

    athens Repository record

  14. Functional characterization of Pura in vivo and in vitro - Pura knock-out mice and Pura DNA unwinding activity

    Ding, HaiyanLudwig-Maximilians-Universität

    … in vivo remains unclear. In this study, Pura knock-out mice (KO) were generated using homologous recombination techniques in ES cells. The Pura gene locus was isolated from 129/SvJ Mouse Genomic Library and partially sequenced. A targeting vector using positive and negative selection was …

    lmu-germany Repository record

  15. A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE

    Carlson, Brittany Leigh Alice2014

    The idea that humans and laboratory animals can become physically dependent on marijuana or its primary psychoactive constituent, delta-9-tetrahydrocannabinol (THC), is gaining acceptance. However, there are no currently approved pharmacotherapies to treat cannabinoid withdrawal. The objective of …

    vcu Repository record

  16. Untersuchung der Rolle des Fas/FasL-Systems bei der Auslösung der Apoptose durch Tumorzellen in Fas-knock out-Makrophagen

    Griesbaum, Sven

    Durch die Dissertationen von Woisetschläger und Wolff wurde ein System etabliert, mit dem es gelang, Wachstum, Differenzierung, Reifegrad und vor allem apoptotische Aktivität bei in in-vitro kultivierten Mausmakrophagen mit Hilfe des immunhistochemischen Nachweises der Apoptosemarker bcl-2, bcl-xL …

    freiburg-diss Repository record

  17. Purification and Characterization of Proteolytic Aspartate Transcarbamoylase (ATCase) from Burkholderia cepacia 25416 and Construction of a pyrB1 Knock-out Mutant

    Kim, SeongcheolUniversity of North Texas2004

    … characteristics of B. cepacia pyrB gene, a pyrB knock-out (pyrB-) was constructed by in vitro mutagenesis. In the assay, the 550 kDa holoenzyme and 140 kDa and 120 kDa trimers disappeared and were replaced with a previously unseen 480 kDa holoenzyme pyrB- strain. The results suggest that B. …

    unt Repository record

  18. Real time course of transmitter release of SSVs and LDCVs; SNARE function analysed in synaptobrevin2 and cellubrevin knock out mice

    Zhao, Ying2012

    Teil 1Die Freisetzung von Neurotransmittern wird durch die Ca2+-abhängige Exocytose von synaptischen Vesikeln vermittelt, die eine sehr schnelle Kinetik der Transmitterfreisetzung aufweist. Mit Hilfe von Kohlefasern als elektrochemische Detektoren wurde die Freisetzung des Neurotransmitters …

    goettingen Repository record

  19. Generation of Endoplasmic Reticulum Protein 28 (ERp28) Knock Out Mice, and Structural and Functional Analysis of its Drosophila Homologue, Wind

    Guo, Chaoshe2012

    … umfasst zwei Teile: (1) die Erstellung von knock-out Mäusen für Erp28, ein Gen, welches für ein Chaperone des Endoplasmatischen Reticulums kodiert, (2) die strukturelle und funktionelle Analyse von Wind, das ERp28-Homolog von Drosophila. Um eine ERp28 Knock-out Maus zu erstellen, musste …

    goettingen Repository record

  20. Application of gene editing methods in the biopharmaceutical field: CRISPR/Cas system assessment for large Knock-Out and large Knock-In

    Bertero, Alessandro, Ammoni, AlessandraUniversità degli Studi di Torino2024

    unito Repository record

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