{"id":{"repo_id":"missouri","oai_identifier":"oai:mospace.umsystem.edu:10355/6273"},"canonical_url":"https://search.dev.ndltd.org/etd/missouri/oai:mospace.umsystem.edu:10355/6273","repository":{"repo_id":"missouri","name":"University of Missouri","base_url":"https://mospace.umsystem.edu/oai/request"},"display":{"title":"Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice","abstract":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Estrogen regulates skeletal muscle mass and function in female. Estrogen may influence skeletal muscle mass and function during development in males as estrogen receptors (ER) have been identified in both female and male skeletal muscle. Whether estrogen exerts its effects on skeletal muscle through estrogen receptor alpha (ER[alpha]) or beta (ER[beta]) or directly during development is unclear. The main purpose of this study was to determine ER knock-out effects on muscle mass and contractile function in muscle with different fiber types, in mature female and male mice that were either ER[alpha] knock out (ER-/-) or ER[beta]-/- with corresponding wild type (WT) groups as controls. Loss of ER[alpha] results in increased Gast and TA muscle in female mice whereas the muscle functions are not affected, and ER[alpha] also influences female Plan muscle function. In contrast, ER[beta] might not have effects on skeletal muscle in female mice. ER-/- and Ar-/- result in decreased Gast and TA muscle in male mice, suggesting that estrogen/ER[alpha] signaling might directly regulate male muscle growth, whereas the muscle function are not affected. In contrast, ER[beta] might not have any effects on skeletal muscle in male mice.","abstract_html":"[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Estrogen regulates skeletal muscle mass and function in female. Estrogen may influence skeletal muscle mass and function during development in males as estrogen receptors (ER) have been identified in both female and male skeletal muscle. Whether estrogen exerts its effects on skeletal muscle through estrogen receptor alpha (ER[alpha]) or beta (ER[beta]) or directly during development is unclear. The main purpose of this study was to determine ER knock-out effects on muscle mass and contractile function in muscle with different fiber types, in mature female and male mice that were either ER[alpha] knock out (ER-/-) or ER[beta]-/- with corresponding wild type (WT) groups as controls. Loss of ER[alpha] results in increased Gast and TA muscle in female mice whereas the muscle functions are not affected, and ER[alpha] also influences female Plan muscle function. In contrast, ER[beta] might not have effects on skeletal muscle in female mice. ER-/- and Ar-/- result in decreased Gast and TA muscle in male mice, suggesting that estrogen/ER[alpha] signaling might directly regulate male muscle growth, whereas the muscle function are not affected. In contrast, ER[beta] might not have any effects on skeletal muscle in male mice.","abstract_has_math":false,"creators":["Ning, Jie"],"institution":"University of Missouri--Columbia","degree_name":"M.S.","degree_level":"Masters","degree_discipline":"Veterinary biomedical sciences (MU)","degree_department":null,"school":null,"contributors":[],"advisors":["Brown, Marybeth"],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007","date_published":"2007","updated_at":"2026-07-24T03:08:43Z","subjects":[],"languages":["eng","English"],"rights":["Access to files is limited to the campuses of the University of Missouri with SSO login."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/6273"],"render_values":[{"text":"https://doi.org/10.32469/10355/6273","href":"https://doi.org/10.32469/10355/6273","code":true}]}]},"links":{"outbound_url":"https://hdl.handle.net/10355/6273","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Brown, Marybeth"]},{"key":"dc:creator","label":"Author","values":["Ning, Jie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-03-03T15:35:23Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-03-03T15:35:23Z"]},{"key":"dc:date.issued","label":"Date","values":["2007"]},{"key":"dc:publisher","label":"Institution","values":["University of Missouri--Columbia"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary biomedical sciences (MU)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Missouri--Columbia"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Access to files is limited to the campuses of the University of Missouri with SSO login."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.32469/10355/6273"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10355/6273"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["\"August 2007\"","The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Vita.","Includes bibliographical references.","Thesis (M.S.) 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Loss of ER[alpha] results in increased Gast and TA muscle in female mice whereas the muscle functions are not affected, and ER[alpha] also influences female Plan muscle function. In contrast, ER[beta] might not have effects on skeletal muscle in female mice. ER-/- and Ar-/- result in decreased Gast and TA muscle in male mice, suggesting that estrogen/ER[alpha] signaling might directly regulate male muscle growth, whereas the muscle function are not affected. In contrast, ER[beta] might not have any effects on skeletal muscle in male mice."]},{"key":"dc:title","label":"Title","values":["Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice"]}]}],"canonical_facts":{"dc:contributor.advisor":["Brown, Marybeth"],"dc:creator":["Ning, Jie"],"dc:date.accessioned":["2010-03-03T15:35:23Z"],"dc:date.available":["2010-03-03T15:35:23Z"],"dc:date.issued":["2007"],"dc:description":["\"August 2007\"","The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.","Vita.","Includes bibliographical references.","Thesis (M.S.) University of Missouri-Columbia 2007.","Dissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences."],"dc:description.abstract":["[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Estrogen regulates skeletal muscle mass and function in female. Estrogen may influence skeletal muscle mass and function during development in males as estrogen receptors (ER) have been identified in both female and male skeletal muscle. Whether estrogen exerts its effects on skeletal muscle through estrogen receptor alpha (ER[alpha]) or beta (ER[beta]) or directly during development is unclear. The main purpose of this study was to determine ER knock-out effects on muscle mass and contractile function in muscle with different fiber types, in mature female and male mice that were either ER[alpha] knock out (ER-/-) or ER[beta]-/- with corresponding wild type (WT) groups as controls. Loss of ER[alpha] results in increased Gast and TA muscle in female mice whereas the muscle functions are not affected, and ER[alpha] also influences female Plan muscle function. In contrast, ER[beta] might not have effects on skeletal muscle in female mice. ER-/- and Ar-/- result in decreased Gast and TA muscle in male mice, suggesting that estrogen/ER[alpha] signaling might directly regulate male muscle growth, whereas the muscle function are not affected. In contrast, ER[beta] might not have any effects on skeletal muscle in male mice."],"dc:identifier.doi":["https://doi.org/10.32469/10355/6273"],"dc:identifier.uri":["https://hdl.handle.net/10355/6273"],"dc:language":["English"],"dc:language.iso":["eng"],"dc:publisher":["University of Missouri--Columbia"],"dc:rights":["Access to files is limited to the campuses of the University of Missouri with SSO login."],"dc:title":["Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice"],"dc:type":["Thesis"],"thesis:degree_discipline":["Veterinary biomedical sciences (MU)"],"thesis:degree_level":["Masters"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Missouri--Columbia"]},"updated_at":"2026-07-24T03:08:43Z"}