Synthesis of Fluoroflavones as Potential Neuroprotective Agents

Flavones are polyphenol natural products that are known to have neuroprotective effects against many diseases caused by the formation of reactive species. Flavonoids are subgroup of flavones and they are believed to function as antioxidants. Specifically, they target free radicals and eliminate its harmful effect on the cell. Fluoroflavones were designed to improve the potency of the antioxidant activity and potentially be used as neuroprotective agents. A monofluorinated and trifluoromethylated flavone were synthesized by using commercially available fluorination reagents, N-fluorobenzenesulfonimide; and Togni’s or Umemoto's respectively. After the synthesis of the desired flavones and their monofluorinated and trifluoromethylated derivatives, biological testing was conducted. First, antioxidant activity was evaluated by using DPPH antioxidant assay and displayed that the fluorinated flavones are more potent compared to their non-fluorinated derivatives. Second, 19 FNMR experiments were conducted to investigate the effect of fluorination on the antioxidant activity of flavones.

Name thesis:degree_name

M.S. in Pharmaceutical Science

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Pharmaceutics and Drug Delivery

Year dc:date.available

2019

Author dc:creator

• Alshammari, Maali

Contributors dc:contributor

• David A. Colby
• Nicole Ashpole
• Sudeshna Roy

• Antioxidant
• Flavones
• Fluorination
• Fluoroflavones
• Pharmacy and Pharmaceutical Sciences

Repository record dc:identifier

https://egrove.olemiss.edu/etd/1587

OAI identifier oai:identifier

oai:egrove.olemiss.edu:etd-2586