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Showing 1 to 20 of 28 for “"Flavones"”.
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
Polymethylated flavones are constituents of many herbs and edible plants in nature. Their broad spectrum of pharmacological activities such as anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-fungal, blood thinning and neuro-protective effects have been reported extensively. To …
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Design and synthesis of novel biologically active flavones and isoflavones
The primary aim of this project was to develop different methodologies for the synthesis of novel 4-arylisoflavans and isoflavenes or analogues that structurally resemble isoflavonoids. In addition, the incorporation of fused-ring systems into the isoflavonoid scaffold to synthesize analogues of a …
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Synthesis of Fluoroflavones as Potential Neuroprotective Agents
Flavones are polyphenol natural products that are known to have neuroprotective effects against many diseases caused by the formation of reactive species. Flavonoids are subgroup of flavones and they are believed to function as antioxidants. Specifically, they target free radicals and eliminate its …
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The effect of UV-B radiation on flavonoid accumulation and gene expression in Marchantia polymorpha
… and in particular flavonoids, of which the flavones were the most predominant. Apigenin-based flavones were found in the highest amounts followed by luteolin-based flavones. The ratio of Apigenin to Luteolin-based flavones was seen to shift towards luteolin in high UV-B responses. Apigenin …
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Progress Toward the Synthesis of 3-Methoxyflavones as Potential Antioxidants, Neuroprotective Agents, and Trifluoromethylated 19F NMR Probes
The total synthesis of polyhydroxylated flavones have proven to be challenging, due to the presence of more than one hydroxyl group. Direct cyclization was not successful in any of the attempts. However, by using a silyl protecting group, the cyclization was feasible. Other reactions like the …
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Flavonoid Consumption of College Athletes
… by flavonols, flavanones, anthocyanidins, and flavones. These rankings are consistent with findings from similar studies. The main food group sources of flavonoids were fruits, beverages, and vegetables. Top five food sources for total flavonoids were black tea, orange juice, onions, apples …
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Relationship Between Flavonoid Structure And Phase-II Metabolism
… and 6) study the regiospecific disposition of flavones in Caco-2 cells. Method: For objectives 1 and 2, in vitro recombinant human UGT isoforms glucuronidation model was used. For objective 3, in silico pharmacophore and 2-D/3-D QSAR modeling was used along with in vitro glucuronidation …
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Metal-free methodology for the preparation of ynones using potassium alkynyltrifluoroborates and its application to the synthesis of natural products
… product scaffolds in good yields. A variety of flavones were obtained via 6-endo cyclization of o-alkynoylphenol intermediates in the presence of trifluoromethanesulfonic acid (TfOH). Cesium carbonate was discovered to promote the rapid 5-exo cyclization of o-alkynoylphenols to form aurone …
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Tannin geochemistry of natural systems: method development and application
… extender units, in addition to flavones, flavanones, triterpenoids, and carboxylic acids.Molecular tannin signatures were obtained from 117 source tissues, including leaves, needles, woods, and barks from tropical and temperate forests, coasts, and grasslands. Conifer needles …
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Cloning, Expression, and Biochemical Characterization of Recombinant Putative Glucosyltransferases Clone 3 and 8 from Grapefruit (Citrus paradisi)
… of flavonoid glycosides such as flavanones and flavones. Flavonoids have a vast array of important functions in plants and also in humans. Glucosyltransferases (GTs) are enzymes responsible for glucosylation reactions. In our pursuit to study the structure and function of flavonoid GTs, we have …
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THE BIOSYNTHSIS OF QUERCETIN IN BUCKWHEAT
… by many workers regarding the biosynthesis of flavones but here again little direct biochemical work has been carried out. It was on the suggestion of Dr. A. C. Neish that this work, on the biogenesis of quercetin, one of the most widely distributed flavonols in nature, was undertaken. The …
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Design and Synthesis of CDK-5 and MEK-5 Inhibitors and Synthesis towards Tubulysin Analogs
… following classes--benzimidazole, diphenylamine, flavones, and ortho-carboxyamide were examined for their capacity to be developed into potent and selective MEK-5 inhibitors. </p><p>Tubulysin is a natural product that disrupts microtubule dynamics, blocks mitosis, and induces cell death. It has …
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A study of methods of preparation of phthalaldehyde
… general field centering around the chalcones, flavones, and anthocyanidins. Members of the three classes of compounds exist as natural products and occur widely as coloring matter in flowers and plant saps.</p><p>An attempt has been made to work out a new method for the preparation of …
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The antioxidant properties of 4–quinolones compared to structurally related flavonoids
… assays to evaluate the potential value of the flavones and synthesised 2-phenylquinolin-4( 1 H)-ones. The oxygen radical absorbance capacity (ORAC) assay was performed to establish the ability of the test series to scavenge peroxyl radicals leading to lipid peroxidation. The 2-phenylquinolin-4( …
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Flavonoid Intake and Prostate Cancer Aggressiveness In African Americans and European Americans
… were found. In addition, flavanones and flavones were significantly inversely associated with aggressiveness for AA men. In general, decreasing risks with increasing intakes were found for flavonols and flavanols, although these odds ratios did not reach statistical significance. …
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Concentration dependency, mode of action and characterization of compounds involved in alfalfa autotoxicity
… the sample had characteristics of chalcones and flavones. Medicarpin was not found in the extract.
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Phytochemical diversity and genetics of purple corn
… identified abundant apigenin-derived flavones that were found to copigment with anthocyanins, resulting in darker and bluer extracts and improved anthocyanin stability in a model beverage. Given the unique phytochemical diversity present in AR, a large-scale AR mapping population was …
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Isolation of novel antibiotic producing microorganisms from invertebrates
… showed that the active components were novel flavones and isoflavones. Such compounds have extracted from plants and only previously been shown to be produced by endophytic fungi. The minimal inhibitory concentrations (MIC) against test bacteria and inhibitory concentration IC50 (IC50 is the …
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Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations
… anthocyanidins (9.5±0.6mg/day), isoflavones (2.4±0.1mg/day), and flavones (1.0±0.0mg/day). The three most dominant individual flavonoids were catechin (167.5±6.1mg/day), epicatechin (68.5±2.3mg/day) and hesperetin (19.1±1.0mg/day). People with high alcohol consumption, low …
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BIOACTIVATION OF NATURAL DIETARY PRODRUGS BY SPECIFIC CYTOCHROME P450 ENZYMES
… of the latent anticancer activity of the flavones. This was confirmed using recombinant CYPlAl microsomes which showed that CYPlAl is the major enzyme catalysing the bioconversion of these citrus flavonoids. CYPl Bl could also metabolise these compounds but to a lesser extent. LC-MS …
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