Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"flavone"”.
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Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage.
… by hydroxyl, sugar, and carbohydrate additions. Flavone is a structurally simple flavonoid. Quercetin and its glycosidic analog rutin are complex structures. Using a DNA oxidation/cleavage assay, flavone reduces DNA nicking by 91%. Depending on the solvent system used, quercetin can either …
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Molecular Definition of Cytochrome P450 -Mediated Multiple Resistance in Helicoverpa Zea
… idole-3-carbinol, chlorogenic acid, and flavone, and by a synthetic chemical not naturally encountered, phenobarbital. Molecular modeling indicated that CYP6B8, representative of the four H. zea CYP6B proteins has more flexible overall folding, a larger and more elastic catalytic pocket, …
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Metal-free methodology for the preparation of ynones using potassium alkynyltrifluoroborates and its application to the synthesis of natural products
… o-alkynoylphenol precursors of aurone and flavone natural product scaffolds in good yields. A variety of flavones were obtained via 6-endo cyclization of o-alkynoylphenol intermediates in the presence of trifluoromethanesulfonic acid (TfOH). Cesium carbonate was discovered to promote the …
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Investigating the modulation of oral drug absorption using in vitro models
… and lemon juices had no effect on the assay. Flavone derivatives had previously been found to be inhibitors of CYP3A4 yet neither naringin nor naringenin had any significant effect at concentrations found in grapefruit juice. Of the other (non-grapefruit) flavone derivatives tested, …
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Synthesis of Fluoroflavones as Potential Neuroprotective Agents
Flavones are polyphenol natural products that are known to have neuroprotective effects against many diseases caused by the formation of reactive species. Flavonoids are subgroup of flavones and they are believed to function as antioxidants. Specifically, they target free radicals and eliminate its …
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Flavonoids and Related Compounds as Nucleoside Transporter Inhibitors
… than the existing ones, a series of 95 different flavone and flavone-like compounds was screened against concentrative nucleoside transporters (CNT 1, 2 and 3) and equilibrative nucleoside transporters (ENT 1 and 2). The results obtained in the form of IC50 values were further utilized to perform …
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The effect of UV-B radiation on flavonoid accumulation and gene expression in Marchantia polymorpha
… and in particular flavonoids, of which the flavones were the most predominant. Apigenin-based flavones were found in the highest amounts followed by luteolin-based flavones. The ratio of Apigenin to Luteolin-based flavones was seen to shift towards luteolin in high UV-B responses. Apigenin …
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Baicalein, a novel anti-diabetic compound
… Studies have reported that baicalein, a flavone originally isolated from the roots of Chinese herb Scutellaria baicalensis, has various claimed beneficial effects on health, such as anti-oxidant, anti-viral, anti-thrombotic, and anti-inflammatory effects. However, it is unclear whether it …
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Liganden des Benzodiazepin-Rezeptors: Studien über Benzodiazepine in pflanzlichen Geweben sowie über Hispidulin
… Extraktes wurden fünf aktive Komponenten, drei Flavone und zwei Diterpene, isoliert. Die BZD-R-aktiven Flavone wurden als Apigenin (5,7,4’-Trihydroxyflavon), Hispidulin (5,7,4’-Trihydroxy-6-methoxyflavon)und Cirsimaritin (5,4’-Dihydroxy-6,7-dimethoxyflavon identifiziert. Bei den diterpenoiden …
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Toxizität und Gentoxizität von Phytohormonen und deren Metaboliten
… die Phytoöstrogene aus den Stoffgruppen der Isoflavone, Cumestane und Indol-3-carbinole. Weit über 100 Pflanzen produzieren Phytohormone. Die bekanntesten sind die Sojabohne, Weintrauben, Leinsamen, Haferflocken, Spargel, Traubensilberkerze und roter Klee. Phytohormone können täglich in großer …
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Study of Polyphenols and Naphthalimide Analogs As Inhibitors of Amyloid- β Protein Aggregation In Alzheimer'S Disease
… In this study, a group of polyphenols, including flavone, apigenin, luteolin, 3'4'-dihydroxyflavone and 5,7,3'4'5'-pentahydroxyflavone, was investigated for their ability to disrupt Aβ fibrils. Results indicate that these polyphenols do not disassociate Aβ fibrils but interrupt Aβ …
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Condensation of terephthalaldehyde and hydroxyacetophenones
… the mother substance of chrysin as being flavone (II), whereas the mother substance of fisetin (III) was flavonol (IV).</p><p>The preparation of terephthalates was investigated in this work. The two methods considered were: (1) The condensation of terephthalaldehyde with the benzoates of …
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Assessment of chemical markers as surrogates for efficacy and safety of Rooibos extracts
… 3-deoxy-dihydrochalcone, nothofagin, and their flavone derivatives.
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Nitrogen and carbon costs of growth and antioxidant production during acclimation to environmental stress in two species of gethyllis
… antioxidant content (total polyphenol, flavonol/flavone and flavanone content) and antioxidant capacity [ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC) and 2,2'-azino-di-3-ethylbenzthiazoline sulphonate (ABTS) radical cation scavenging ability] of natural …
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Molecular and biochemical characterization of hydroxyjasmonate and flavonoid sulfotransferases from Arabidopsis thaliana
… was found to accept a number of flavonols and flavone aglycones, as well as their monosulfate derivatives. The AtST3a is expressed only at the earlier stage of seedling development. In contrast, the expression pattern of the flavonol 3-ST from Flaveria species is detectable at all stages of …
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TOWARDS UNDERSTANDING MODE-OF-ACTION OF TRADITIONAL MEDICINES BY USING IN SILICO TARGET PREDICTION
… space revealed that benzene, anthraquinone, flavone, sterol, pentacyclic triterpene and cyclohexene were the most frequent scaffolds in those TM. The annotation of the bioactivity space with target classes showed that kinase class was the most significant target class for all groups. From a …
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Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations
… anthocyanidins (9.5±0.6mg/day), isoflavones (2.4±0.1mg/day), and flavones (1.0±0.0mg/day). The three most dominant individual flavonoids were catechin (167.5±6.1mg/day), epicatechin (68.5±2.3mg/day) and hesperetin (19.1±1.0mg/day). People with high alcohol consumption, low …
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Φυτοχημική ανάλυση-Βιολογικές δράσεις -Αιθέριων ελαίων του υβριδίου ''Eugene'' και των γονεικών ειδών Citrus latifolia var.latifolia και Citrus limon cv. Zampetaki, -Primula vulgaris Huds.
… εκ των οποίων οι 4 ήταν μεθόξυ παράγωγα • flavone • 2’-methoxyflavone • 3’-methoxyflavone • 3’-hydroxy, 4’,5’-dimethoxyflavone • 5,6,2',3',6'-pentamethoxyflavone (πρώτη φορά στο είδος) 2ii) Ενώ από το μεθανολικό εκχύλισμα απομονώθηκαν και ταυτοποιήθηκαν 2 γλυκοσίδες φλαβονοειδών • …
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The antioxidant properties of 4–quinolones compared to structurally related flavonoids
… observed for the flavonoids. As a result, the flavone moiety was selected as the lead compound, substituted with hydroxyl groups on different positions and were compared to the correlating hydroxyl substituted 2-phenylquinolin-4(1 H)-ones, which were prepared by the Conrad-Limpach method and …
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… by trans-chalcone, sulforaphane, curcumin, flavone, kahweol, and carnosol, which were all more potent and effective than tBHQ. None of the natural compounds were more potent than CDDO-Im. In conclusion, Nrf2-target genes are involved in NADPH generation, NADPH-facilitated oxidative stress …
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