Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery

The objective of this study was to develop a novel multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester (LDI) or 1,6-Diisocyanatohexane (HDI). The gelation temperature of 20% (w/v) MBCP was in the range of 29 to 31 ºC when tested with three different techniques: rheometer, test tube inversion method, and falling ball method. The polymer shopH-triggered degradation and drug release with nile red and irinotecan. The ketal linker connecting Pluronic® was cleaved and resulted in smaller molecular weight strain causing change in sol-gel transition temperature and critical micelle concentration. This mechanism confers the synthesized polymer with pH/temperature instigated drug release properties and thus can be used for targeted drug delivery applications.

Name thesis:degree_name

M.S. in Pharmaceutical Science

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Pharmaceutics and Drug Delivery

Year dc:date.available

2017

Author dc:creator

• Lee, Hyung Kyung

Contributors dc:contributor

• Seongbong Jo
• Michael A. Repka
• Soumyajit Majumdar

• Acid labile
• Pluronic
• temperature sensitive
• Pharmacy and Pharmaceutical Sciences

Repository record dc:identifier

https://egrove.olemiss.edu/etd/1335

OAI identifier oai:identifier

oai:egrove.olemiss.edu:etd-2334