{"id":{"repo_id":"mississippi","oai_identifier":"oai:egrove.olemiss.edu:etd-2334"},"canonical_url":"https://search.dev.ndltd.org/etd/mississippi/oai:egrove.olemiss.edu:etd-2334","repository":{"repo_id":"mississippi","name":"University of Mississippi","base_url":"https://egrove.olemiss.edu/do/oai/"},"display":{"title":"Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery","abstract":"The objective of this study was to develop a novel multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester (LDI) or 1,6-Diisocyanatohexane (HDI). The gelation temperature of 20% (w/v) MBCP was in the range of 29 to 31 ºC when tested with three different techniques: rheometer, test tube inversion method, and falling ball method. The polymer shopH-triggered degradation and drug release with nile red and irinotecan. The ketal linker connecting Pluronic® was cleaved and resulted in smaller molecular weight strain causing change in sol-gel transition temperature and critical micelle concentration. This mechanism confers the synthesized polymer with pH/temperature instigated drug release properties and thus can be used for targeted drug delivery applications.","abstract_html":"The objective of this study was to develop a novel multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester (LDI) or 1,6-Diisocyanatohexane (HDI). The gelation temperature of 20% (w/v) MBCP was in the range of 29 to 31 ºC when tested with three different techniques: rheometer, test tube inversion method, and falling ball method. The polymer shopH-triggered degradation and drug release with nile red and irinotecan. The ketal linker connecting Pluronic® was cleaved and resulted in smaller molecular weight strain causing change in sol-gel transition temperature and critical micelle concentration. This mechanism confers the synthesized polymer with pH/temperature instigated drug release properties and thus can be used for targeted drug delivery applications.","abstract_has_math":false,"creators":["Lee, Hyung Kyung"],"institution":null,"degree_name":"M.S. in Pharmaceutical Science","degree_level":"Thesis","degree_discipline":"Pharmaceutics and Drug Delivery","degree_department":null,"school":null,"contributors":["Seongbong Jo","Michael A. Repka","Soumyajit Majumdar"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-01-01T08:00:00Z","date_published":"2017-01-01T08:00:00Z","updated_at":"2026-07-24T03:06:44Z","subjects":["Acid labile","Pluronic","temperature sensitive","Pharmacy and Pharmaceutical Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://egrove.olemiss.edu/etd/1335","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Seongbong Jo","Michael A. Repka","Soumyajit Majumdar"]},{"key":"dc:creator","label":"Author","values":["Lee, Hyung Kyung"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2020-01-23T08:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Pharmaceutics and Drug Delivery"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S. in Pharmaceutical Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Acid labile","Pluronic","temperature sensitive","Pharmacy and Pharmaceutical Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://egrove.olemiss.edu/etd/1335"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The objective of this study was to develop a novel multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester (LDI) or 1,6-Diisocyanatohexane (HDI). The gelation temperature of 20% (w/v) MBCP was in the range of 29 to 31 ºC when tested with three different techniques: rheometer, test tube inversion method, and falling ball method. The polymer shopH-triggered degradation and drug release with nile red and irinotecan. The ketal linker connecting Pluronic® was cleaved and resulted in smaller molecular weight strain causing change in sol-gel transition temperature and critical micelle concentration. This mechanism confers the synthesized polymer with pH/temperature instigated drug release properties and thus can be used for targeted drug delivery applications."]},{"key":"dc:title","label":"Title","values":["Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery"]}]}],"canonical_facts":{"dc:contributor":["Seongbong Jo","Michael A. Repka","Soumyajit Majumdar"],"dc:creator":["Lee, Hyung Kyung"],"dc:date.available":["2020-01-23T08:00:00Z"],"dc:description.abstract":["The objective of this study was to develop a novel multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate ethyl ester (LDI) or 1,6-Diisocyanatohexane (HDI). The gelation temperature of 20% (w/v) MBCP was in the range of 29 to 31 ºC when tested with three different techniques: rheometer, test tube inversion method, and falling ball method. The polymer shopH-triggered degradation and drug release with nile red and irinotecan. The ketal linker connecting Pluronic® was cleaved and resulted in smaller molecular weight strain causing change in sol-gel transition temperature and critical micelle concentration. This mechanism confers the synthesized polymer with pH/temperature instigated drug release properties and thus can be used for targeted drug delivery applications."],"dc:identifier":["https://egrove.olemiss.edu/etd/1335"],"dc:subject":["Acid labile","Pluronic","temperature sensitive","Pharmacy and Pharmaceutical Sciences"],"dc:title":["Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery"],"thesis:degree_discipline":["Pharmaceutics and Drug Delivery"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S. in Pharmaceutical Science"]},"updated_at":"2026-07-24T03:06:44Z"}