Università degli Studi di Milano
A MOLECULAR UNDERSTANDING OF ANEUPLOID CELL CLEARANCE
Abstract
dc:descriptionChromosome segregation errors can lead to aneuploidy, an abnormal chromosome number associated with cancer and genome instability. My Ph.D. research focused on understanding the interplay between aneuploid cells and the immune system. By utilising mass spectrometry and the Surfaceome database, I identified plasma membrane molecules differentially expressed between aneuploid and euploid cells. This study unveiled key molecules with a crucial role in the recognition and elimination of aneuploid cells by Natural Killer cells. This discovery offers a promising tool for eradicating tumor cells and suggests innovative therapeutic strategies in cancer treatment. Beyond understanding aneuploidy's consequences, this research opens avenues for leveraging the immune system more efficiently in the battle against cancer
Degree
thesis:*- Grantor dc:publisher
- Università degli Studi di Milano
- Year dc:date
- 2024
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- MARTIS, VALENTINO
- Contributors dc:contributor
-
- tutor: S. Santaguida ; coordinatore: S. Minucci
- V. Martis
- SANTAGUIDA, STEFANO
- MINUCCI, SAVERIO
Subjects
dc:subject × 1Rights
dc:rights- Statement dc:rights
-
- info:eu-repo/semantics/embargoedAccess
- license:Creative commons
- license uri:http://creativecommons.org/licenses/by-sa/4.0/
- Language dc:language
- eng
Identifiers
dc:identifier.*- Handle dc:identifier
- https://hdl.handle.net/2434/1038248
- OAI identifier oai:identifier
- oai:air.unimi.it:2434/1038248