A MOLECULAR UNDERSTANDING OF ANEUPLOID CELL CLEARANCE
type: CreativeWork
description: Chromosome segregation errors can lead to aneuploidy, an abnormal chromosome number associated with cancer and genome instability. My Ph.D. research focused on understanding the interplay between aneuploid cells and the immune system. By utilising mass spectrometry and the Surfaceome database, I identified plasma membrane molecules differentially expressed between aneuploid and euploid cells. This study unveiled key molecules with a crucial role in the recognition and elimination of aneuploid cells by Natural Killer cells. This discovery offers a promising tool for eradicating tumor cells and suggests innovative therapeutic strategies in cancer treatment. Beyond understanding aneuploidy's consequences, this research opens avenues for leveraging the immune system more efficiently in the battle against cancer
abstract: Chromosome segregation errors can lead to aneuploidy, an abnormal chromosome number associated with cancer and genome instability. My Ph.D. research focused on understanding the interplay between aneuploid cells and the immune system. By utilising mass spectrometry and the Surfaceome database, I identified plasma membrane molecules differentially expressed between aneuploid and euploid cells. This study unveiled key molecules with a crucial role in the recognition and elimination of aneuploid cells by Natural Killer cells. This discovery offers a promising tool for eradicating tumor cells and suggests innovative therapeutic strategies in cancer treatment. Beyond understanding aneuploidy's consequences, this research opens avenues for leveraging the immune system more efficiently in the battle against cancer
author: MARTIS, VALENTINO
language: eng
keywords: Settore BIO/11 - Biologia Molecolare
date published: 2024-04-11
date modified: 2026-07-27T20:18:48Z
provider: Università degli Studi di Milano
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Università degli Studi di Milano

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2434/1038248